Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
1_MDYDF 6_ KVKLS 11_ SERER 16_ VEDLF 21_ EYEGC 26_ KVGRG 31_ TYGHV 36_ YKAKR 41_ KDGKD 46_ DKDYA 51_ LKQIE 56_ GTGIS 61_ MSACR 66_ EIALL 71_ RELKH 76_ PNVIS 81_ LQKVF 86_ LSHAD 91_ RKVWL 96_ LFDYA 101_ EHDLW 106_ HIIKF 111_ HRASK 116_ ANKKP 121_ VQLPR 126_ GMVKS 131_ LLYQI 136_ LDGIH 141_ YLHAN 146_ WVLHR 151_ DLKPA 156_ NILVM 161_ GEGPE 166_ RGRVK 171_ IADMG 176_ FARLF 181_ NSPLK 186_ PLADL 191_ DPVVV 196_ TFWYR 201_ APELL 206_ LGARH 211_ YTKAI 216_ DIWAI 221_ GCIFA 226_ ELLTS 231_ EPIFH 236_ CRQED 241_ IKTSN 246_ PYHHD 251_ QLDRI 256_ FNVMG 261_ FPADK 266_ DWEDI 271_ KKMPE 276_ HSTLM 281_ KDFRR 286_ NTYTN 291_ CSLIK 296_ YMEKH 301_ KVKPD 306_ SKAFH 311_ LLQKL 316_ LTMDP 321_ IKRIT 326_ SEQAM 331_ QDPYF 336_ LEDPL 341_ PTSDV 346_ FAGCQ 351_ IPYPK 356_ REFLT 361_ EEEPD 366_ DKGDK 371_ KNQQQ 376_ QQGNN 381_ HTNGT 386_ GHPGN 391_ QDSSH 396_ TQGPP 401_ LKKVR 406_ VVPPT 411_ TTSGG 416_ LIMTS 421_ DYQRS 426_ NPHAA 431_ YPNPG 436_ PSTSQ 441_ PQSSM 446_ GYSAT 451_ SQQPP 456_QYSHQ
1: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation