Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha)
1_MAATE 6_ GVGEA 11_ AQGGE 16_ PGQPA 21_ QPPPQ 26_ PHPPP 31_ PQQQH 36_ KEEMA 41_ AEAGE 46_ AVASP 51_ MDDGF 56_ VSLDS 61_ PSYVL 66_ YRDRA 71_ EWADI 76_ DPVPQ 81_ NDGPN 86_ PVVQI 91_ IYSDK 96_ FRDVY 101_ DYFRA 106_ VLQRD 111_ ERSER 116_ AFKLT 121_ RDAIE 126_ LNAAN 131_ YTVWH 136_ FRRVL 141_ LKSLQ 146_ KDLHE 151_ EMNYI 156_ TAIIE 161_ EQPKN 166_ YQVWH 171_ HRRVL 176_ VEWLR 181_ DPSQE 186_ LEFIA 191_ DILNQ 196_ DAKNY 201_ HAWQH 206_ RQWVI 211_ QEFKL 216_ WDNEL 221_ QYVDQ 226_ LLKED 231_ VRNNS 236_ VWNQR 241_ YFVIS 246_ NTTGY 251_ NDRAV 256_ LEREV 261_ QYTLE 266_ MIKLV 271_ PHNES 276_ AWNYL 281_ KGILQ 286_ DRGLS 291_ KYPNL 296_ LNQLL 301_ DLQPS 306_ HSSPY 311_ LIAFL 316_ VDIYE 321_ DMLEN 326_ QCDNK 331_ EDILN 336_ KALEL 341_ CEILA 346_ KEKDT 351_ IRKEY 356_ WRYIG 361_ RSLQS 366_ KHSTE 371_NDSPT
1: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation