Deoxyhypusine synthase (DHS) (EC 2.5.1.46)
1_MEGSL 6_ EREAP 11_ AGALA 16_ AVLKH 21_ SSTLP 26_ PESTQ 31_ VRGYD 36_ FNRGV 41_ NYRAL 46_ LEAFG 51_ TTGFQ 56_ ATNFG 61_ RAVQQ 66_ VNAMI 71_ EKKLE 76_ PLSQD 81_ EDQHA 86_ DLTQS 91_ RRPLT 96_ SCTIF 101_ LGYTS 106_ NLISS 111_ GIRET 116_ IRYLV 121_ QHNMV 126_ DVLVT 131_ TAGGV 136_ EEDLI 141_ KCLAP 146_ TYLGE 151_ FSLRG 156_ KELRE 161_ NGINR 166_ IGNLL 171_ VPNEN 176_ YCKFE 181_ DWLMP 186_ ILDQM 191_ VMEQN 196_ TEGVK 201_ WTPSK 206_ MIARL 211_ GKEIN 216_ NPESV 221_ YYWAQ 226_ KNHIP 231_ VFSPA 236_ LTDGS 241_ LGDMI 246_ FFHSY 251_ KNPGL 256_ VLDIV 261_ EDLRL 266_ INTQA 271_ IFAKC 276_ TGMII 281_ LGGGV 286_ VKHHI 291_ ANANL 296_ MRNGA 301_ DYAVY 306_ INTAQ 311_ EFDGS 316_ DSGAR 321_ PDEAV 326_ SWGKI 331_ RVDAQ 336_ PVKVY 341_ ADASL 346_ VFPLL 351_ VAETF 356_ AQKMD 361_AFMHE
1: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function