Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
1_MGPRR 6_ RSRKP 11_ EAPRR 16_ RSPSP 21_ TPTPG 26_ PSRRG 31_ PSLGA 36_ SSHQH 41_ SRRRQ 46_ GWLKE 51_ IRKLQ 56_ KSTHL 61_ LIRKL 66_ PFSRL 71_ AREIC 76_ VKFTR 81_ GVDFN 86_ WQAQA 91_ LLALQ 96_ EAAEA 101_ FLVHL 106_ FEDAY 111_ LLTLH 116_ AGRVT 121_ LFPKD 126_ VQLAR 131_RIRGL
1: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, PubMed:7962047, PubMed:9024683). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore (PubMed:18072184). The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3 (PubMed:26878239, PubMed:27499292). May serve as an epigenetic mark that propagates centromere identity through replication and cell division (PubMed:15282608, PubMed:15475964, PubMed:20739937, PubMed:21478274, PubMed:26878239). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:11756469, PubMed:14667408, PubMed:18072184, PubMed:23818633, PubMed:25556658, PubMed:27499292)