Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42)
1_MDSTL 6_ TASEI 11_ RQRFI 16_ DFFKR 21_ NEHTY 26_ VHSSA 31_ TIPLD 36_ DPTLL 41_ FANAG 46_ MNQFK 51_ PIFLN 56_ TIDPS 61_ HPMAK 66_ LSRAA 71_ NTQKC 76_ IRAGG 81_ KHNDL 86_ DDVGK 91_ DVYHH 96_ TFFEM 101_ LGSWS 106_ FGDYF 111_ KELAC 116_ KMALE 121_ LLTQE 126_ FGIPI 131_ ERLYV 136_ TYFGG 141_ DEAAG 146_ LEADL 151_ ECKQI 156_ WQNLG 161_ LDDTK 166_ ILPGN 171_ MKDNF 176_ WEMGD 181_ TGPCG 186_ PCSEI 191_ HYDRI 196_ GGRDA 201_ AHLVN 206_ QDDPN 211_ VLEIW 216_ NLVFI 221_ QYNRE 226_ ADGIL 231_ KPLPK 236_ KSIDT 241_ GMGLE 246_ RLVSV 251_ LQNKM 256_ SNYDT 261_ DLFVP 266_ YFEAI 271_ QKGTG 276_ ARPYT 281_ GKVGA 286_ EDADG 291_ IDMAY 296_ RVLAD 301_ HARTI 306_ TVALA 311_ DGGRP 316_ DNTGR 321_ GYVLR 326_ RILRR 331_ AVRYA 336_ HEKLN 341_ ASRGF 346_ FATLV 351_ DVVVQ 356_ SLGDA 361_ FPELK 366_ KDPDM 371_ VKDII 376_ NEEEV 381_ QFLKT 386_ LSRGR 391_ RILDR 396_ KIQSL 401_ GDSKT 406_ IPGDT 411_ AWLLY 416_ DTYGF 421_ PVDLT 426_ GLIAE 431_ EKGLV 436_ VDMDG 441_ FEEER 446_ KLAQL 451_ KSQGK 456_ GAGGE 461_ DLIML 466_ DIYAI 471_ EELRA 476_ RGLEV 481_ TDDSP 486_ KYNYH 491_ LDSSG 496_ SYVFE 501_ NTVAT 506_ VMALR 511_ REKMF 516_ VEEVS 521_ TGQEC 526_ GVVLD 531_ KTCFY 536_ AEQGG 541_ QIYDE 546_ GYLVK 551_ VDDSS 556_ EDKTE 561_ FTVKN 566_ AQVRG 571_ GYVLH 576_ IGTIY 581_ GDLKV 586_ GDQVW 591_ LFIDE 596_ PRRRP 601_ IMSNH 606_ TATHI 611_ LNFAL 616_ RSVLG 621_ EADQK 626_ GSLVA 631_ PDRLR 636_ FDFTA 641_ KGAMS 646_ TQQIK 651_ KAEEI 656_ ANEMI 661_ EAAKA 666_ VYTQD 671_ CPLAA 676_ AKAIQ 681_ GLRAV 686_ FDETY 691_ PDPVR 696_ VVSIG 701_ VPVSE 706_ LLDDP 711_ SGPAG 716_ SLTSV 721_ EFCGG 726_ THLRN 731_ SSHAG 736_ AFVIV 741_ TEEAI 746_ AKGIR 751_ RIVAV 756_ TGAEA 761_ QKALR 766_ KAESL 771_ KKCLS 776_ VMEAK 781_ VKAQT 786_ APNKD 791_ VQREI 796_ ADLGE 801_ ALATA 806_ VIPQW 811_ QKDEL 816_ RETLK 821_ SLKKV 826_ MDDLD 831_ RASKA 836_ DVQKR 841_ VLEKT 846_ KQFID 851_ SNPNQ 856_ PLVIL 861_ EMESG 866_ ASAKA 871_ LNEAL 876_ KLFKM 881_ HSPQT 886_ SAMLF 891_ TVDNE 896_ AGKIT 901_ CLCQV 906_ PQNAA 911_ NRGLK 916_ ASEWV 921_ QQVSG 926_ LMDGK 931_ GGGKD 936_ VSAQA 941_ TGKNV 946_ GCLQE 951_ ALQLA 956_ TSFAQ 961_LRLGD
1: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:33909043). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:27622773, PubMed:27911835, PubMed:28493438, PubMed:29273753). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1 (PubMed:38512451, PubMed:38653238). Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins (PubMed:38512451, PubMed:38653238, PubMed:39322678). Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53 (PubMed:38653238). Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1 (PubMed:38512451)