Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)
1_MVLDL 6_ DLFRV 11_ DKGGD 16_ PALIR 21_ ETQEK 26_ RFKDP 31_ GLVDQ 36_ LVKAD 41_ SEWRR 46_ CRFRA 51_ DNLNK 56_ LKNLC 61_ SKTIG 66_ EKMKK 71_ KEPVG 76_ DDESV 81_ PENVL 86_ SFDDL 91_ TADAL 96_ ANLKV 101_ SQIKK 106_ VRLLI 111_ DEAIL 116_ KCDAE 121_ RIKLE 126_ AERFE 131_ NLREI 136_ GNLLH 141_ PSVPI 146_ SNDED 151_ VDNKV 156_ ERIWG 161_ DCTVR 166_ KKYSH 171_ VDLVV 176_ MVDGF 181_ EGEKG 186_ AVVAG 191_ SRGYF 196_ LKGVL 201_ VFLEQ 206_ ALIQY 211_ ALRTL 216_ GSRGY 221_ IPIYT 226_ PFFMR 231_ KEVMQ 236_ EVAQL 241_ SQFDE 246_ ELYKV 251_ IGKGS 256_ EKSDD 261_ NSYDE 266_ KYLIA 271_ TSEQP 276_ IAALH 281_ RDEWL 286_ RPEDL 291_ PIKYA 296_ GLSTC 301_ FRQEV 306_ GSHGR 311_ DTRGI 316_ FRVHQ 321_ FEKIE 326_ QFVYS 331_ SPHDN 336_ KSWEM 341_ FEEMI 346_ TTAEE 351_ FYQSL 356_ GIPYH 361_ IVNIV 366_ SGSLN 371_ HAASK 376_ KLDLE 381_ AWFPG 386_ SGAFR 391_ ELVSC 396_ SNCTD 401_ YQARR 406_ LRIRY 411_ GQTKK 416_ MMDKV 421_ EFVHM 426_ LNATM 431_ CATTR 436_ TICAI 441_ LENYQ 446_ TEKGI 451_ TVPEK 456_ LKEFM 461_ PPGLQ 466_ ELIPF 471_ VKPAP 476_ IEQEP 481_ SKKQK 486_ KQHEG 491_ SKKKA 496_ AARDV 501_ TLENR 506_LQNME
1: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000)