Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
1_MELRV 6_ GNKYR 11_ LGRKI 16_ GSGSF 21_ GDIYL 26_ GANIA 31_ SGEEV 36_ AIKLE 41_ CVKTK 46_ HPQLH 51_ IESKF 56_ YKMMQ 61_ GGVGI 66_ PSIKW 71_ CGAEG 76_ DYNVM 81_ VMELL 86_ GPSLE 91_ DLFNF 96_ CSRKF 101_ SLKTV 106_ LLLAD 111_ QMISR 116_ IEYIH 121_ SKNFI 126_ HRDVK 131_ PDNFL 136_ MGLGK 141_ KGNLV 146_ YIIDF 151_ GLAKK 156_ YRDAR 161_ THQHI 166_ PYREN 171_ KNLTG 176_ TARYA 181_ SINTH 186_ LGIEQ 191_ SRRDD 196_ LESLG 201_ YVLMY 206_ FNLGS 211_ LPWQG 216_ LKAAT 221_ KRQKY 226_ ERISE 231_ KKMST 236_ PIEVL 241_ CKGYP 246_ SEFST 251_ YLNFC 256_ RSLRF 261_ DDKPD 266_ YSYLR 271_ QLFRN 276_ LFHRQ 281_ GFSYD 286_ YVFDW 291_ NMLKF 296_ GAARN 301_ PEDVD 306_ RERRE 311_ HEREE 316_ RMGQL 321_ RGSAT 326_ RALPP 331_ GPPTG 336_ ATANR 341_ LRSAA 346_ EPVAS 351_ TPASR 356_ IQPAG 361_ NTSPR 366_ AISRV 371_ DRERK 376_ VSMRL 381_ HRGAP 386_ ANVSS 391_ SDLTG 396_ RQEVS 401_ RIPAS 406_ QTSVP 411_FDHLG
1: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676)