C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
1_MVLEV 6_ SDHQV 11_ LNDAE 16_ VAALL 21_ ENFSS 26_ SYDYG 31_ ENESD 36_ SCCTS 41_ PPCPQ 46_ DFSLN 51_ FDRAF 56_ LPALY 61_ SLLFL 66_ LGLLG 71_ NGAVA 76_ AVLLS 81_ RRTAL 86_ SSTDT 91_ FLLHL 96_ AVADT 101_ LLVLT 106_ LPLWA 111_ VDAAV 116_ QWVFG 121_ SGLCK 126_ VAGAL 131_ FNINF 136_ YAGAL 141_ LLACI 146_ SFDRY 151_ LNIVH 156_ ATQLY 161_ RRGPP 166_ ARVTL 171_ TCLAV 176_ WGLCL 181_ LFALP 186_ DFIFL 191_ SAHHD 196_ ERLNA 201_ THCQY 206_ NFPQV 211_ GRTAL 216_ RVLQL 221_ VAGFL 226_ LPLLV 231_ MAYCY 236_ AHILA 241_ VLLVS 246_ RGQRR 251_ LRAMR 256_ LVVVV 261_ VVAFA 266_ LCWTP 271_ YHLVV 276_ LVDIL 281_ MDLGA 286_ LARNC 291_ GRESR 296_ VDVAK 301_ SVTSG 306_ LGYMH 311_ CCLNP 316_ LLYAF 321_ VGVKF 326_ RERMW 331_ MLLLR 336_ LGCPN 341_ QRGLQ 346_ RQPSS 351_ SRRDS 356_ SWSET 361_SEASY
1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling
2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis
3: Mediates the activity of CXCL11