G-protein coupled receptor 15 (Brother of Bonzo) (BoB)
1_MDPEE 6_ TSVYL 11_ DYYYA 16_ TSPNS 21_ DIRET 26_ HSHVP 31_ YTSVF 36_ LPVFY 41_ TAVFL 46_ TGVLG 51_ NLVLM 56_ GALHF 61_ KPGSR 66_ RLIDI 71_ FIINL 76_ AASDF 81_ IFLVT 86_ LPLWV 91_ DKEAS 96_ LGLWR 101_ TGSFL 106_ CKGSS 111_ YMISV 116_ NMHCS 121_ VLLLT 126_ CMSVD 131_ RYLAI 136_ VWPVV 141_ SRKFR 146_ RTDCA 151_ YVVCA 156_ SIWFI 161_ SCLLG 166_ LPTLL 171_ SRELT 176_ LIDDK 181_ PYCAE 186_ KKATP 191_ IKLIW 196_ SLVAL 201_ IFTFF 206_ VPLLS 211_ IVTCY 216_ CCIAR 221_ KLCAH 226_ YQQSG 231_ KHNKK 236_ LKKSI 241_ KIIFI 246_ VVAAF 251_ LVSWL 256_ PFNTF 261_ KFLAI 266_ VSGLR 271_ QEHYL 276_ PSAIL 281_ QLGME 286_ VSGPL 291_ AFANS 296_ CVNPF 301_ IYYIF 306_ DSYIR 311_ RAIVH 316_ CLCPC 321_ LKNYD 326_ FGSST 331_ ETSDS 336_ HLTKA 341_ LSTFI 346_ HAEDF 351_ARRRK
1: G protein-coupled receptor that plays an important role in immune homeostasis (PubMed:33758080, PubMed:38918398). Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (PubMed:33758080, PubMed:38918398). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35510660)
2: (Microbial infection) Acts as an alternative coreceptor with CD4 for HIV-1 infection