Transcriptional repressor CTCF (11-zinc finger protein) (CCCTC-binding factor) (CTCFL paralog)
1_MEGDA 6_ VEAIV 11_ EESET 16_ FIKGK 21_ ERKTY 26_ QRRRE 31_ GGQEE 36_ DACHL 41_ PQNQT 46_ DGGEV 51_ VQDVN 56_ SSVQM 61_ VMMEQ 66_ LDPTL 71_ LQMKT 76_ EVMEG 81_ TVAPE 86_ AEAAV 91_ DDTQI 96_ ITLQV 101_ VNMEE 106_ QPINI 111_ GELQL 116_ VQVPV 121_ PVTVP 126_ VATTS 131_ VEELQ 136_ GAYEN 141_ EVSKE 146_ GLAES 151_ EPMIC 156_ HTLPL 161_ PEGFQ 166_ VVKVG 171_ ANGEV 176_ ETLEQ 181_ GELPP 186_ QEDPS 191_ WQKDP 196_ DYQPP 201_ AKKTK 206_ KTKKS 211_ KLRYT 216_ EEGKD 221_ VDVSV 226_ YDFEE 231_ EQQEG 236_ LLSEV 241_ NAEKV 246_ VGNMK 251_ PPKPT 256_ KIKKK 261_ GVKKT 266_ FQCEL 271_ CSYTC 276_ PRRSN 281_ LDRHM 286_ KSHTD 291_ ERPHK 296_ CHLCG 301_ RAFRT 306_ VTLLR 311_ NHLNT 316_ HTGTR 321_ PHKCP 326_ DCDMA 331_ FVTSG 336_ ELVRH 341_ RRYKH 346_ THEKP 351_ FKCSM 356_ CDYAS 361_ VEVSK 366_ LKRHI 371_ RSHTG 376_ ERPFQ 381_ CSLCS 386_ YASRD 391_ TYKLK 396_ RHMRT 401_ HSGEK 406_ PYECY 411_ ICHAR 416_ FTQSG 421_ TMKMH 426_ ILQKH 431_ TENVA 436_ KFHCP 441_ HCDTV 446_ IARKS 451_ DLGVH 456_ LRKQH 461_ SYIEQ 466_ GKKCR 471_ YCDAV 476_ FHERY 481_ ALIQH 486_ QKSHK 491_ NEKRF 496_ KCDQC 501_ DYACR 506_ QERHM 511_ IMHKR 516_ THTGE 521_ KPYAC 526_ SHCDK 531_ TFRQK 536_ QLLDM 541_ HFKRY 546_ HDPNF 551_ VPAAF 556_ VCSKC 561_ GKTFT 566_ RRNTM 571_ ARHAD 576_ NCAGP 581_ DGVEG 586_ ENGGE 591_ TKKSK 596_ RGRKR 601_ KMRSK 606_ KEDSS 611_ DSENA 616_ EPDLD 621_ DNEDE 626_ EEPAV 631_ EIEPE 636_ PEPQP 641_ VTPAP 646_ PPAKK 651_ RRGRP 656_ PGRTN 661_ QPKQN 666_ QPTAI 671_ IQVED 676_ QNTGA 681_ IENII 686_ VEVKK 691_ EPDAE 696_ PAEGE 701_ EEEAQ 706_ PAATD 711_ APNGD 716_ LTPEM 721_ILSMM
1: Chromatin binding factor that binds to DNA sequence specific sites and regulates the 3D structure of chromatin (PubMed:18347100, PubMed:18654629, PubMed:19322193). Binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures, such as the nuclear lamina (PubMed:18347100, PubMed:18654629, PubMed:19322193). Defines the boundaries between active and heterochromatic DNA via binding to chromatin insulators, thereby preventing interaction between promoter and nearby enhancers and silencers (PubMed:18347100, PubMed:18654629, PubMed:19322193). Plays a critical role in the epigenetic regulation (PubMed:16949368). Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus (PubMed:16107875, PubMed:16815976, PubMed:17827499). On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2 (By similarity). Mediates interchromosomal association between IGF2/H19 and WSB1/NF1 and may direct distant DNA segments to a common transcription factory (By similarity). Regulates asynchronous replication of IGF2/H19 (By similarity). Plays a critical role in gene silencing over considerable distances in the genome (By similarity). Preferentially interacts with unmethylated DNA, preventing spreading of CpG methylation and maintaining methylation-free zones (PubMed:18413740). Inversely, binding to target sites is prevented by CpG methylation (PubMed:18413740). Plays an important role in chromatin remodeling (PubMed:18413740). Can dimerize when it is bound to different DNA sequences, mediating long-range chromatin looping (PubMed:12191639). Causes local loss of histone acetylation and gain of histone methylation in the beta-globin locus, without affecting transcription (PubMed:12191639). When bound to chromatin, it provides an anchor point for nucleosomes positioning (PubMed:12191639). Seems to be essential for homologous X-chromosome pairing (By similarity). May participate with Tsix in establishing a regulatable epigenetic switch for X chromosome inactivation (PubMed:11743158). May play a role in preventing the propagation of stable methylation at the escape genes from X-inactivation (PubMed:11743158). Involved in sister chromatid cohesion (PubMed:12191639). Associates with both centromeres and chromosomal arms during metaphase and required for cohesin localization to CTCF sites (PubMed:18550811). Plays a role in the recruitment of CENPE to the pericentromeric/centromeric regions of the chromosome during mitosis (PubMed:26321640). Acts as a transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene (PubMed:18413740, PubMed:8649389, PubMed:9591631). Also binds to the PLK and PIM1 promoters (PubMed:12191639). Acts as a transcriptional activator of APP (PubMed:9407128). Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression (PubMed:18347100, PubMed:19322193). Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription (By similarity). Seems to act as tumor suppressor (PubMed:12191639)