Proteasome subunit beta type-3 (Proteasome chain 13) (Proteasome component C10-II) (Proteasome theta chain)
1_MSIMS 6_ YNGGA 11_ VMAMK 16_ GKNCV 21_ AIAAD 26_ RRFGI 31_ QAQMV 36_ TTDFQ 41_ KIFPM 46_ GDRLY 51_ IGLAG 56_ LATDV 61_ QTVAQ 66_ RLKFR 71_ LNLYE 76_ LKEGR 81_ QIKPY 86_ TLMSM 91_ VANLL 96_ YEKRF 101_ GPYYT 106_ EPVIA 111_ GLDPK 116_ TFKPF 121_ ICSLD 126_ LIGCP 131_ MVTDD 136_ FVVSG 141_ TCAEQ 146_ MYGMC 151_ ESLWE 156_ PNMDP 161_ DHLFE 166_ TISQA 171_ MLNAV 176_ DRDAV 181_ SGMGV 186_ IVHII 191_ EKDKI 196_TTRTL
1: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)