Proteasome subunit beta type-2 (Macropain subunit C7-I) (Multicatalytic endopeptidase complex subunit C7-I) (Proteasome component C7-I)
1_MEYLI 6_ GIQGP 11_ DYVLV 16_ ASDRV 21_ AASNI 26_ VQMKD 31_ DHDKM 36_ FKMSE 41_ KILLL 46_ CVGEA 51_ GDTVQ 56_ FAEYI 61_ QKNVQ 66_ LYKMR 71_ NGYEL 76_ SPTAA 81_ ANFTR 86_ RNLAD 91_ CLRSR 96_ TPYHV 101_ NLLLA 106_ GYDEH 111_ EGPAL 116_ YYMDY 121_ LAALA 126_ KAPFA 131_ AHGYG 136_ AFLTL 141_ SILDR 146_ YYTPT 151_ ISRER 156_ AVELL 161_ RKCLE 166_ ELQKR 171_ FILNL 176_ PTFSV 181_ RIIDK 186_ NGIHD 191_ LDNIS 196_FPKQG
1: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex)