DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)
1_MAESS 6_ ESFTM 11_ ASSPA 16_ QRRRG 21_ NDPLT 26_ SSPGR 31_ SSRRT 36_ DALTS 41_ SPGRD 46_ LPPFE 51_ DESEG 56_ LLGTE 61_ GPLEE 66_ EEDGE 71_ ELIGD 76_ GMERD 81_ YRAIP 86_ ELDAY 91_ EAEGL 96_ ALDDE 101_ DVEEL 106_ TASQR 111_ EAAER 116_ AMRQR 121_ DREAG 126_ RGLGR 131_ MRRGL 136_ LYDSD 141_ EEDEE 146_ RPARK 151_ RRQVE 156_ RATED 161_ GEEDE 166_ EMIES 171_ IENLE 176_ DLKGH 181_ SVREW 186_ VSMAG 191_ PRLEI 196_ HHRFK 201_ NFLRT 206_ HVDSH 211_ GHNVF 216_ KERIS 221_ DMCKE 226_ NRESL 231_ VVNYE 236_ DLAAR 241_ EHVLA 246_ YFLPE 251_ APAEL 256_ LQIFD 261_ EAALE 266_ VVLAM 271_ YPKYD 276_ RITNH 281_ IHVRI 286_ SHLPL 291_ VEELR 296_ SLRQL 301_ HLNQL 306_ IRTSG 311_ VVTSC 316_ TGVLP 321_ QLSMV 326_ KYNCN 331_ KCNFV 336_ LGPFC 341_ QSQNQ 346_ EVKPG 351_ SCPEC 356_ QSAGP 361_ FEVNM 366_ EETIY 371_ QNYQR 376_ IRIQE 381_ SPGKV 386_ AAGRL 391_ PRSKD 396_ AILLA 401_ DLVDS 406_ CKPGD 411_ EIELT 416_ GIYHN 421_ NYDGS 426_ LNTAN 431_ GFPVF 436_ ATVIL 441_ ANHVA 446_ KKDNK 451_ VAVGE 456_ LTDED 461_ VKMIT 466_ SLSKD 471_ QQIGE 476_ KIFAS 481_ IAPSI 486_ YGHED 491_ IKRGL 496_ ALALF 501_ GGEPK 506_ NPGGK 511_ HKVRG 516_ DINVL 521_ LCGDP 526_ GTAKS 531_ QFLKY 536_ IEKVS 541_ SRAIF 546_ TTGQG 551_ ASAVG 556_ LTAYV 561_ QRHPV 566_ SREWT 571_ LEAGA 576_ LVLAD 581_ RGVCL 586_ IDEFD 591_ KMNDQ 596_ DRTSI 601_ HEAME 606_ QQSIS 611_ ISKAG 616_ IVTSL 621_ QARCT 626_ VIAAA 631_ NPIGG 636_ RYDPS 641_ LTFSE 646_ NVDLT 651_ EPIIS 656_ RFDIL 661_ CVVRD 666_ TVDPV 671_ QDEML 676_ ARFVV 681_ GSHVR 686_ HHPSN 691_ KEEEG 696_ LANGS 701_ AAEPA 706_ MPNTY 711_ GVEPL 716_ PQEVL 721_ KKYII 726_ YAKER 731_ VHPKL 736_ NQMDQ 741_ DKVAK 746_ MYSDL 751_ RKESM 756_ ATGSI 761_ PITVR 766_ HIESM 771_ IRMAE 776_ AHARI 781_ HLRDY 786_ VIEDD 791_ VNMAI 796_ RVMLE 801_ SFIDT 806_ QKFSV 811_ MRSMR 816_ KTFAR 821_ YLSFR 826_ RDNNE 831_ LLLFI 836_ LKQLV 841_ AEQVT 846_ YQRNR 851_ FGAQQ 856_ DTIEV 861_ PEKDL 866_ VDKAR 871_ QINIH 876_ NLSAF 881_ YDSEL 886_ FRMNK 891_ FSHDL 896_KRKMI
1: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677)