Cartilage oligomeric matrix protein (COMP) (Thrombospondin-5) (TSP5)
1_MVPDT 6_ ACVLL 11_ LTLAA 16_ LGASG 21_ QGQSP 26_ LGSDL 31_ GPQML 36_ RELQE 41_ TNAAL 46_ QDVRE 51_ LLRQQ 56_ VREIT 61_ FLKNT 66_ VMECD 71_ ACGMQ 76_ QSVRT 81_ GLPSV 86_ RPLLH 91_ CAPGF 96_ CFPGV 101_ ACIQT 106_ ESGAR 111_ CGPCP 116_ AGFTG 121_ NGSHC 126_ TDVNE 131_ CNAHP 136_ CFPRV 141_ RCINT 146_ SPGFR 151_ CEACP 156_ PGYSG 161_ PTHQG 166_ VGLAF 171_ AKANK 176_ QVCTD 181_ INECE 186_ TGQHN 191_ CVPNS 196_ VCINT 201_ RGSFQ 206_ CGPCQ 211_ PGFVG 216_ DQASG 221_ CQRRA 226_ QRFCP 231_ DGSPS 236_ ECHEH 241_ ADCVL 246_ ERDGS 251_ RSCVC 256_ AVGWA 261_ GNGIL 266_ CGRDT 271_ DLDGF 276_ PDEKL 281_ RCPER 286_ QCRKD 291_ NCVTV 296_ PNSGQ 301_ EDVDR 306_ DGIGD 311_ ACDPD 316_ ADGDG 321_ VPNEK 326_ DNCPL 331_ VRNPD 336_ QRNTD 341_ EDKWG 346_ DACDN 351_ CRSQK 356_ NDDQK 361_ DTDQD 366_ GRGDA 371_ CDDDI 376_ DGDRI 381_ RNQAD 386_ NCPRV 391_ PNSDQ 396_ KDSDG 401_ DGIGD 406_ ACDNC 411_ PQKSN 416_ PDQAD 421_ VDHDF 426_ VGDAC 431_ DSDQD 436_ QDGDG 441_ HQDSR 446_ DNCPT 451_ VPNSA 456_ QEDSD 461_ HDGQG 466_ DACDD 471_ DDDND 476_ GVPDS 481_ RDNCR 486_ LVPNP 491_ GQEDA 496_ DRDGV 501_ GDVCQ 506_ DDFDA 511_ DKVVD 516_ KIDVC 521_ PENAE 526_ VTLTD 531_ FRAFQ 536_ TVVLD 541_ PEGDA 546_ QIDPN 551_ WVVLN 556_ QGREI 561_ VQTMN 566_ SDPGL 571_ AVGYT 576_ AFNGV 581_ DFEGT 586_ FHVNT 591_ VTDDD 596_ YAGFI 601_ FGYQD 606_ SSSFY 611_ VVMWK 616_ QMEQT 621_ YWQAN 626_ PFRAV 631_ AEPGI 636_ QLKAV 641_ KSSTG 646_ PGEQL 651_ RNALW 656_ HTGDT 661_ ESQVR 666_ LLWKD 671_ PRNVG 676_ WKDKK 681_ SYRWF 686_ LQHRP 691_ QVGYI 696_ RVRFY 701_ EGPEL 706_ VADSN 711_ VVLDT 716_ TMRGG 721_ RLGVF 726_ CFSQE 731_ NIIWA 736_ NLRYR 741_ CNDTI 746_ PEDYE 751_THQLR
1: Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors (PubMed:16051604, PubMed:16542502). Could play a role in the pathogenesis of osteoarthritis (PubMed:16542502). Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (PubMed:17993464). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity)