Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (VLCAD) (EC 1.3.8.9)
1_MQAAR 6_ MAASL 11_ GRQLL 16_ RLGGG 21_ SSRLT 26_ ALLGQ 31_ PRPGP 36_ ARRPY 41_ AGGAA 46_ QLALD 51_ KSDSH 56_ PSDAL 61_ TRKKP 66_ AKAES 71_ KSFAV 76_ GMFKG 81_ QLTTD 86_ QVFPY 91_ PSVLN 96_ EEQTQ 101_ FLKEL 106_ VEPVS 111_ RFFEE 116_ VNDPA 121_ KNDAL 126_ EMVEE 131_ TTWQG 136_ LKELG 141_ AFGLQ 146_ VPSEL 151_ GGVGL 156_ CNTQY 161_ ARLVE 166_ IVGMH 171_ DLGVG 176_ ITLGA 181_ HQSIG 186_ FKGIL 191_ LFGTK 196_ AQKEK 201_ YLPKL 206_ ASGET 211_ VAAFC 216_ LTEPS 221_ SGSDA 226_ ASIRT 231_ SAVPS 236_ PCGKY 241_ YTLNG 246_ SKLWI 251_ SNGGL 256_ ADIFT 261_ VFAKT 266_ PVTDP 271_ ATGAV 276_ KEKIT 281_ AFVVE 286_ RGFGG 291_ ITHGP 296_ PEKKM 301_ GIKAS 306_ NTAEV 311_ FFDGV 316_ RVPSE 321_ NVLGE 326_ VGSGF 331_ KVAMH 336_ ILNNG 341_ RFGMA 346_ AALAG 351_ TMRGI 356_ IAKAV 361_ DHATN 366_ RTQFG 371_ EKIHN 376_ FGLIQ 381_ EKLAR 386_ MVMLQ 391_ YVTES 396_ MAYMV 401_ SANMD 406_ QGATD 411_ FQIEA 416_ AISKI 421_ FGSEA 426_ AWKVT 431_ DECIQ 436_ IMGGM 441_ GFMKE 446_ PGVER 451_ VLRDL 456_ RIFRI 461_ FEGTN 466_ DILRL 471_ FVALQ 476_ GCMDK 481_ GKELS 486_ GLGSA 491_ LKNPF 496_ GNAGL 501_ LLGEA 506_ GKQLR 511_ RRAGL 516_ GSGLS 521_ LSGLV 526_ HPELS 531_ RSGEL 536_ AVRAL 541_ EQFAT 546_ VVEAK 551_ LIKHK 556_ KGIVN 561_ EQFLL 566_ QRLAD 571_ GAIDL 576_ YAMVV 581_ VLSRA 586_ SRSLS 591_ EGHPT 596_ AQHEK 601_ MLCDT 606_ WCIEA 611_ AARIR 616_ EGMAA 621_ LQSDP 626_ WQQEL 631_ YRNFK 636_ SISKA 641_ LVERG 646_GVVTS
1: Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948)