Vacuolar protein sorting-associated protein 41 homolog (S53)
1_MAEAE 6_ EQETG 11_ SLEES 16_ TDESE 21_ EEESE 26_ EEPKL 31_ KYERL 36_ SNGVT 41_ EILQK 46_ DAASC 51_ MTVHD 56_ KFLAL 61_ GTHYG 66_ KVYLL 71_ DVQGN 76_ ITQKF 81_ DVSPV 86_ KINQI 91_ SLDES 96_ GEHMG 101_ VCSED 106_ GKVQV 111_ FGLYS 116_ GEEFH 121_ ETFDC 126_ PIKII 131_ AVHPH 136_ FVRSS 141_ CKQFV 146_ TGGKK 151_ LLLFE 156_ RSWMN 161_ RWKSA 166_ VLHEG 171_ EGNIR 176_ SVKWR 181_ GHLIA 186_ WANNM 191_ GVKIF 196_ DIISK 201_ QRITN 206_ VPRDD 211_ ISLRP 216_ DMYPC 221_ SLCWK 226_ DNVTL 231_ IIGWG 236_ TSVKV 241_ CSVKE 246_ RHASE 251_ MRDLP 256_ SRYVE 261_ IVSQF 266_ ETEFY 271_ ISGLA 276_ PLCDQ 281_ LVVLS 286_ YVKEI 291_ SEKTE 296_ REYCA 301_ RPRLD 306_ IIQPL 311_ SETCE 316_ EISSD 321_ ALTVR 326_ GFQEN 331_ ECRDY 336_ HLEYS 341_ EGESL 346_ FYIVS 351_ PRDVV 356_ VAKER 361_ DQDDH 366_ IDWLL 371_ EKKKY 376_ EEALM 381_ AAEIS 386_ QKNIK 391_ RHKIL 396_ DIGLA 401_ YINHL 406_ VERGD 411_ YDIAA 416_ RKCQK 421_ ILGKN 426_ AALWE 431_ YEVYK 436_ FKEIG 441_ QLKAI 446_ SPYLP 451_ RGDPV 456_ LKPLI 461_ YEMIL 466_ HEFLE 471_ SDYEG 476_ FATLI 481_ REWPG 486_ DLYNN 491_ SVIVQ 496_ AVRDH 501_ LKKDS 506_ QNKTL 511_ LKTLA 516_ ELYTY 521_ DKNYG 526_ NALEI 531_ YLTLR 536_ HKDVF 541_ QLIHK 546_ HNLFS 551_ SIKDK 556_ IVLLM 561_ DFDSE 566_ KAVDM 571_ LLDNE 576_ DKISI 581_ KKVVE 586_ ELEDR 591_ PELQH 596_ VYLHK 601_ LFKRD 606_ HHKGQ 611_ RYHEK 616_ QISLY 621_ AEYDR 626_ PNLLP 631_ FLRDS 636_ THCPL 641_ EKALE 646_ ICQQR 651_ NFVEE 656_ TVYLL 661_ SRMGN 666_ SRSAL 671_ KMIME 676_ ELHDV 681_ DKAIE 686_ FAKEQ 691_ DDGEL 696_ WEDLI 701_ LYSID 706_ KPPFI 711_ TGLLN 716_ NIGTH 721_ VDPIL 726_ LIHRI 731_ KEGME 736_ IPNLR 741_ DSLVK 746_ ILQDY 751_ NLQIL 756_ LREGC 761_ KKILV 766_ ADSLS 771_ LLKKM 776_ HRTQM 781_ KGVLV 786_ DEENI 791_ CESCL 796_ SPILP 801_ SDAAK 806_ PFSVV 811_ VFHCR 816_ HMFHK 821_ ECLPM 826_ PSMNS 831_ AAQFC 836_ NICSA 841_ KNRGP 846_GSAIL
1: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the HOPS endosomal tethering complex. This complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085, PubMed:33851776). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:23167963, PubMed:25445562, PubMed:25908847, PubMed:9159129). Required for fusion of autophagosomes with lysosomes (PubMed:25783203, PubMed:37821429). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:21802320, PubMed:25445562, PubMed:25908847). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660)