RNA-binding protein 25 (Arg/Glu/Asp-rich protein of 120 kDa) (RED120) (Protein S164) (RNA-binding motif protein 25) (RNA-binding region-containing protein 7)
1_MSFPP 6_ HLNRP 11_ PMGIP 16_ ALPPG 21_ IPPPQ 26_ FPGFP 31_ PPVPP 36_ GTPMI 41_ PVPMS 46_ IMAPA 51_ PTVLV 56_ PTVSM 61_ VGKHL 66_ GARKD 71_ HPGLK 76_ AKEND 81_ ENCGP 86_ TTTVF 91_ VGNIS 96_ EKASD 101_ MLIRQ 106_ LLAKC 111_ GLVLS 116_ WKRVQ 121_ GASGK 126_ LQAFG 131_ FCEYK 136_ EPEST 141_ LRALR 146_ LLHDL 151_ QIGEK 156_ KLLVK 161_ VDAKT 166_ KAQLD 171_ EWKAK 176_ KKASN 181_ GNARP 186_ ETVTN 191_ DDEEA 196_ LDEET 201_ KRRDQ 206_ MIKGA 211_ IEVLI 216_ REYSS 221_ ELNAP 226_ SQESD 231_ SHPRK 236_ KKKEK 241_ KEDIF 246_ RRFPV 251_ APLIP 256_ YPLIT 261_ KEDIN 266_ AIEME 271_ EDKRD 276_ LISRE 281_ ISKFR 286_ DTHKK 291_ LEEEK 296_ GKKEK 301_ ERQEI 306_ EKERR 311_ ERERE 316_ RERER 321_ ERRER 326_ ERERE 331_ RERER 336_ EKEKE 341_ RERER 346_ ERDRD 351_ RDRTK 356_ ERDRD 361_ RDRER 366_ DRDRD 371_ RERSS 376_ DRNKD 381_ RSRSR 386_ EKSRD 391_ RERER 396_ ERERE 401_ RERER 406_ ERERE 411_ RERER 416_ ERERE 421_ RERER 426_ EKDKK 431_ RDREE 436_ DEEDA 441_ YERRK 446_ LERKL 451_ REKEA 456_ AYQER 461_ LKNWE 466_ IRERK 471_ KTREY 476_ EKEAE 481_ REEER 486_ RREMA 491_ KEAKR 496_ LKEFL 501_ EDYDD 506_ DRDDP 511_ KYYRG 516_ SALQK 521_ RLRDR 526_ EKEME 531_ ADERD 536_ RKREK 541_ EELEE 546_ IRQRL 551_ LAEGH 556_ PDPDA 561_ ELQRM 566_ EQEAE 571_ RRRQP 576_ QIKQE 581_ PESEE 586_ EEEEK 591_ QEKEE 596_ KREEP 601_ MEEEE 606_ EPEQK 611_ PCLKP 616_ TLRPI 621_ SSAPS 626_ VSSAS 631_ GNATP 636_ NTPGD 641_ ESPCG 646_ IIIPH 651_ ENSPD 656_ QQQPE 661_ EHRPK 666_ IGLSL 671_ KLGAS 676_ NSPGQ 681_ PNSVK 686_ RKKLP 691_ VDSVF 696_ NKFED 701_ EDSDD 706_ VPRKR 711_ KLVPL 716_ DYGED 721_ DKNAT 726_ KGTVN 731_ TEEKR 736_ KHIKS 741_ LIEKI 746_ PTAKP 751_ ELFAY 756_ PLDWS 761_ IVDSI 766_ LMERR 771_ IRPWI 776_ NKKII 781_ EYIGE 786_ EEATL 791_ VDFVC 796_ SKVMA 801_ HSSPQ 806_ SILDD 811_ VAMVL 816_ DEEAE 821_ VFIVK 826_ MWRLL 831_ IYETE 836_AKKIG
1: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure