Regulator of G-protein signaling 6 (RGS6) (S914)
1_MAQGS 6_ GDQRA 11_ VGVAD 16_ PEESS 21_ PNMIV 26_ YCKIE 31_ DIITK 36_ MQDDK 41_ TGGVP 46_ IRTVK 51_ SFLSK 56_ IPSVV 61_ TGTDI 66_ VQWLM 71_ KNLSI 76_ EDPVE 81_ AIHLG 86_ SLIAA 91_ QGYIF 96_ PISDH 101_ VLTMK 106_ DDGTF 111_ YRFQA 116_ PYFWP 121_ SNCWE 126_ PENTD 131_ YAIYL 136_ CKRTM 141_ QNKAR 146_ LELAD 151_ YEAEN 156_ LARLQ 161_ RAFAR 166_ KWEFI 171_ FMQAE 176_ AQVKI 181_ DRKKD 186_ KTERK 191_ ILDSQ 196_ ERAFW 201_ DVHRP 206_ VPGCV 211_ NTTEM 216_ DIRKC 221_ RRLKN 226_ PQKVK 231_ KSVYG 236_ VTEES 241_ QAQSP 246_ VHVLS 251_ QPIRK 256_ TTKED 261_ IRKQI 266_ TFLNA 271_ QIDRH 276_ CLKMS 281_ KVAES 286_ LIAYT 291_ EQYVE 296_ YDPLI 301_ TPAEP 306_ SNPWI 311_ SDDVA 316_ LWDIE 321_ MSKEP 326_ SQQRV 331_ KRWGF 336_ SFDEI 341_ LKDQV 346_ GRDQF 351_ LRFLE 356_ SEFSS 361_ ENLRF 366_ WLAVQ 371_ DLKKQ 376_ PLQDV 381_ AKRVE 386_ EIWQE 391_ FLAPG 396_ APSAI 401_ NLDSH 406_ SYEIT 411_ SQNVK 416_ DGGRY 421_ TFEDA 426_ QEHIY 431_ KLMKS 436_ DSYAR 441_ FLRSN 446_ AYQDL 451_ LLAKK 456_ KGKSL 461_ AGKRL 466_TGLMQ
1: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509)