Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)
1_MRHSK 6_ RTYCP 11_ DWDDK 16_ DWDYG 21_ KWRSS 26_ SSHKR 31_ RKRSH 36_ SSAQE 41_ NKRCK 46_ YNHSK 51_ MCDSH 56_ YLESR 61_ SINEK 66_ DYHSR 71_ RYIDE 76_ YRNDY 81_ TQGCE 86_ PGHRQ 91_ RDHES 96_ RYQNH 101_ SSKSS 106_ GRSGR 111_ SSYKS 116_ KHRIH 121_ HSTSH 126_ RRSHG 131_ KSHRR 136_ KRTRS 141_ VEDDE 146_ EGHLI 151_ CQSGD 156_ VLSAR 161_ YEIVD 166_ TLGEG 171_ AFGKV 176_ VECID 181_ HKAGG 186_ RHVAV 191_ KIVKN 196_ VDRYC 201_ EAARS 206_ EIQVL 211_ EHLNT 216_ TDPNS 221_ TFRCV 226_ QMLEW 231_ FEHHG 236_ HICIV 241_ FELLG 246_ LSTYD 251_ FIKEN 256_ GFLPF 261_ RLDHI 266_ RKMAY 271_ QICKS 276_ VNFLH 281_ SNKLT 286_ HTDLK 291_ PENIL 296_ FVQSD 301_ YTEAY 306_ NPKIK 311_ RDERT 316_ LINPD 321_ IKVVD 326_ FGSAT 331_ YDDEH 336_ HSTLV 341_ STRHY 346_ RAPEV 351_ ILALG 356_ WSQPC 361_ DVWSI 366_ GCILI 371_ EYYLG 376_ FTVFP 381_ THDSK 386_ EHLAM 391_ MERIL 396_ GPLPK 401_ HMIQK 406_ TRKRK 411_ YFHHD 416_ RLDWD 421_ EHSSA 426_ GRYVS 431_ RRCKP 436_ LKEFM 441_ LSQDV 446_ EHERL 451_ FDLIQ 456_ KMLEY 461_ DPAKR 466_ ITLRE 471_ ALKHP 476_FFDLL
1: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:10480872, PubMed:19168442). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (PubMed:19168442)