Dual specificity protein kinase CLK3 (EC 2.7.12.1) (CDC-like kinase 3)
1_MPVLS 6_ ARRRE 11_ LADHA 16_ GSGRR 21_ SGPSP 26_ TARSG 31_ PHLSA 36_ LRAQP 41_ ARAAH 46_ LSGRG 51_ TYVRR 56_ DTAGG 61_ GPGQA 66_ RPLGP 71_ PGTSL 76_ LGRGA 81_ RRSGE 86_ GWCPG 91_ AFESG 96_ ARAAR 101_ PPSRV 106_ EPRLA 111_ TAASR 116_ EGAGL 121_ PRAEV 126_ AAGSG 131_ RGARS 136_ GEWGL 141_ AAAGA 146_ WETMH 151_ HCKRY 156_ RSPEP 161_ DPYLS 166_ YRWKR 171_ RRSYS 176_ REHEG 181_ RLRYP 186_ SRREP 191_ PPRRS 196_ RSRSH 201_ DRLPY 206_ QRRYR 211_ ERRDS 216_ DTYRC 221_ EERSP 226_ SFGED 231_ YYGPS 236_ RSRHR 241_ RRSRE 246_ RGPYR 251_ TRKHA 256_ HHCHK 261_ RRTRS 266_ CSSAS 271_ SRSQQ 276_ SSKRS 281_ SRSVE 286_ DDKEG 291_ HLVCR 296_ IGDWL 301_ QERYE 306_ IVGNL 311_ GEGTF 316_ GKVVE 321_ CLDHA 326_ RGKSQ 331_ VALKI 336_ IRNVG 341_ KYREA 346_ ARLEI 351_ NVLKK 356_ IKEKD 361_ KENKF 366_ LCVLM 371_ SDWFN 376_ FHGHM 381_ CIAFE 386_ LLGKN 391_ TFEFL 396_ KENNF 401_ QPYPL 406_ PHVRH 411_ MAYQL 416_ CHALR 421_ FLHEN 426_ QLTHT 431_ DLKPE 436_ NILFV 441_ NSEFE 446_ TLYNE 451_ HKSCE 456_ EKSVK 461_ NTSIR 466_ VADFG 471_ SATFD 476_ HEHHT 481_ TIVAT 486_ RHYRP 491_ PEVIL 496_ ELGWA 501_ QPCDV 506_ WSIGC 511_ ILFEY 516_ YRGFT 521_ LFQTH 526_ ENREH 531_ LVMME 536_ KILGP 541_ IPSHM 546_ IHRTR 551_ KQKYF 556_ YKGGL 561_ VWDEN 566_ SSDGR 571_ YVKEN 576_ CKPLK 581_ SYMLQ 586_ DSLEH 591_ VQLFD 596_ LMRRM 601_ LEFDP 606_ AQRIT 611_ LAEAL 616_ LHPFF 621_ AGLTP 626_ EERSF 631_HTSRN
1: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells