Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
1_MTELP 6_ APLSY 11_ FQNAQ 16_ MSEDN 21_ HLSNT 26_ VRSQN 31_ DNRER 36_ QEHND 41_ RRSLG 46_ HPEPL 51_ SNGRP 56_ QGNSR 61_ QVVEQ 66_ DEEED 71_ EELTL 76_ KYGAK 81_ HVIML 86_ FVPVT 91_ LCMVV 96_ VVATI 101_ KSVSF 106_ YTRKD 111_ GQLIY 116_ TPFTE 121_ DTETV 126_ GQRAL 131_ HSILN 136_ AAIMI 141_ SVIVV 146_ MTILL 151_ VVLYK 156_ YRCYK 161_ VIHAW 166_ LIISS 171_ LLLLF 176_ FFSFI 181_ YLGEV 186_ FKTYN 191_ VAVDY 196_ ITVAL 201_ LIWNF 206_ GVVGM 211_ ISIHW 216_ KGPLR 221_ LQQAY 226_ LIMIS 231_ ALMAL 236_ VFIKY 241_ LPEWT 246_ AWLIL 251_ AVISV 256_ YDLVA 261_ VLCPK 266_ GPLRM 271_ LVETA 276_ QERNE 281_ TLFPA 286_ LIYSS 291_ TMVWL 296_ VNMAE 301_ GDPEA 306_ QRRVS 311_ KNSKY 316_ NAEST 321_ ERESQ 326_ DTVAE 331_ NDDGG 336_ FSEEW 341_ EAQRD 346_ SHLGP 351_ HRSTP 356_ ESRAA 361_ VQELS 366_ SSILA 371_ GEDPE 376_ ERGVK 381_ LGLGD 386_ FIFYS 391_ VLVGK 396_ ASATA 401_ SGDWN 406_ TTIAC 411_ FVAIL 416_ IGLCL 421_ TLLLL 426_ AIFKK 431_ ALPAL 436_ PISIT 441_ FGLVF 446_ YFATD 451_ YLVQP 456_ FMDQL 461_AFHQF
1: Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10206644, PubMed:10545183, PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:12679784, PubMed:12740439, PubMed:15274632, PubMed:20460383, PubMed:25043039, PubMed:26280335, PubMed:28269784, PubMed:30598546, PubMed:30630874). Requires the presence of the other members of the gamma-secretase complex for protease activity (PubMed:15274632, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (PubMed:10593990, PubMed:10811883, PubMed:10899933, PubMed:9738936). Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin) (PubMed:11953314). Under conditions of apoptosis or calcium influx, cleaves CDH1 (PubMed:11953314). This promotes the disassembly of the complexes between CDH1 and CTNND1, JUP and CTNNB1, increases the pool of cytoplasmic CTNNB1, and thereby negatively regulates Wnt signaling (PubMed:11953314, PubMed:9738936). Required for normal embryonic brain and skeleton development, and for normal angiogenesis (By similarity). Mediates the proteolytic cleavage of EphB2/CTF1 into EphB2/CTF2 (PubMed:17428795, PubMed:28269784). The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is therefore involved in calcium homeostasis (PubMed:16959576, PubMed:25394380). Involved in the regulation of neurite outgrowth (PubMed:15004326, PubMed:20460383). Is a regulator of presynaptic facilitation, spike transmission and synaptic vesicles replenishment in a process that depends on gamma-secretase activity. It acts through the control of SYT7 presynaptic expression (By similarity)