Translation initiation factor eIF-2B subunit beta (S20I15) (S20III15) (eIF-2B GDP-GTP exchange factor subunit beta)
1_MPGSA 6_ AKGSE 11_ LSERI 16_ ESFVE 21_ TLKRG 26_ GGPRS 31_ SEEMA 36_ RETLG 41_ LLRQI 46_ ITDHR 51_ WSNAG 56_ ELMEL 61_ IRREG 66_ RRMTA 71_ AQPSE 76_ TTVGN 81_ MVRRV 86_ LKIIR 91_ EEYGR 96_ LHGRS 101_ DESDQ 106_ QESLH 111_ KLLTS 116_ GGLNE 121_ DFSFH 126_ YAQLQ 131_ SNIIE 136_ AINEL 141_ LVELE 146_ GTMEN 151_ IAAQA 156_ LEHIH 161_ SNEVI 166_ MTIGF 171_ SRTVE 176_ AFLKE 181_ AARKR 186_ KFHVI 191_ VAECA 196_ PFCQG 201_ HEMAV 206_ NLSKA 211_ GIETT 216_ VMTDA 221_ AIFAV 226_ MSRVN 231_ KVIIG 236_ TKTIL 241_ ANGAL 246_ RAVTG 251_ THTLA 256_ LAAKH 261_ HSTPL 266_ IVCAP 271_ MFKLS 276_ PQFPN 281_ EEDSF 286_ HKFVA 291_ PEEVL 296_ PFTEG 301_ DILEK 306_ VSVHC 311_ PVFDY 316_ VPPEL 321_ ITLFI 326_ SNIGG 331_ NAPSY 336_ IYRLM 341_ SELYH 346_PDDHV
1: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)