Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP)
1_MPTPH 6_ EAEKQ 11_ ITGPE 16_ EADRP 21_ PSMSS 26_ HDTAS 31_ PAAPS 36_ RNPCC 41_ LCWCC 46_ CCSCS 51_ WNQER 56_ RRAWQ 61_ ASRES 66_ KLQPL 71_ PSCEV 76_ CATPS 81_ PEEVQ 86_ SWAQS 91_ FDKLM 96_ HSPAG 101_ RSVFR 106_ AFLRT 111_ EYSEE 116_ NMLFW 121_ LACEE 126_ LKAEA 131_ NQHVV 136_ DEKAR 141_ LIYED 146_ YVSIL 151_ SPKEV 156_ SLDSR 161_ VREGI 166_ NKKMQ 171_ EPSAH 176_ TFDDA 181_ QLQIY 186_ TLMHR 191_ DSYPR 196_ FLSSP 201_ TYRAL 206_ LLQGP 211_SQSSS
1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein