Regulator of G-protein signaling 7 (RGS7)
1_MAQGN 6_ NYGQT 11_ SNGVA 16_ DESPN 21_ MLVYR 26_ KMEDV 31_ IARMQ 36_ DEKNG 41_ IPIRT 46_ VKSFL 51_ SKIPS 56_ VFSGS 61_ DIVQW 66_ LIKNL 71_ TIEDP 76_ VEALH 81_ LGTLM 86_ AAHGY 91_ FFPIS 96_ DHVLT 101_ LKDDG 106_ TFYRF 111_ QTPYF 116_ WPSNC 121_ WEPEN 126_ TDYAV 131_ YLCKR 136_ TMQNK 141_ ARLEL 146_ ADYEA 151_ ESLAR 156_ LQRAF 161_ ARKWE 166_ FIFMQ 171_ AEAQA 176_ KVDKK 181_ RDKIE 186_ RKILD 191_ SQERA 196_ FWDVH 201_ RPVPG 206_ CVNTT 211_ EVDIK 216_ KSSRM 221_ RNPHK 226_ TRKSV 231_ YGLQN 236_ DIRSH 241_ SPTHT 246_ PTPET 251_ KPPTE 256_ DELQQ 261_ QIKYW 266_ QIQLD 271_ RHRLK 276_ MSKVA 281_ DSLLS 286_ YTEQY 291_ LEYDP 296_ FLLPP 301_ DPSNP 306_ WLSDD 311_ TTFWE 316_ LEASK 321_ EPSQQ 326_ RVKRW 331_ GFGMD 336_ EALKD 341_ PVGRE 346_ QFLKF 351_ LESEF 356_ SSENL 361_ RFWLA 366_ VEDLK 371_ KRPIK 376_ EVPSR 381_ VQEIW 386_ QEFLA 391_ PGAPS 396_ AINLD 401_ SKSYD 406_ KTTQN 411_ VKEPG 416_ RYTFE 421_ DAQEH 426_ IYKLM 431_ KSDSY 436_ PRFIR 441_ SSAYQ 446_ ELLQA 451_ KKKSG 456_ NSMDR 461_ RTSFE 466_ KFAQN 471_ VGRNI 476_ PIFPC 481_ HKNCT 486_PTLRA
1: GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed:10521509, PubMed:10862767, PubMed:31189666). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). May play a role in synaptic vesicle exocytosis (Probable) (PubMed:12659861). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264)