Presenilin-2 (PS-2) (EC 3.4.23.-) (AD3LP) (AD5) (E5-1) (STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]
1_MLTFM 6_ ASDSE 11_ EEVCD 16_ ERTSL 21_ MSAES 26_ PTPRS 31_ CQEGR 36_ QGPED 41_ GENTA 46_ QWRSQ 51_ ENEED 56_ GEEDP 61_ DRYVC 66_ SGVPG 71_ RPPGL 76_ EEELT 81_ LKYGA 86_ KHVIM 91_ LFVPV 96_ TLCMI 101_ VVVAT 106_ IKSVR 111_ FYTEK 116_ NGQLI 121_ YTPFT 126_ EDTPS 131_ VGQRL 136_ LNSVL 141_ NTLIM 146_ ISVIV 151_ VMTIF 156_ LVVLY 161_ KYRCY 166_ KFIHG 171_ WLIMS 176_ SLMLL 181_ FLFTY 186_ IYLGE 191_ VLKTY 196_ NVAMD 201_ YPTLL 206_ LTVWN 211_ FGAVG 216_ MVCIH 221_ WKGPL 226_ VLQQA 231_ YLIMI 236_ SALMA 241_ LVFIK 246_ YLPEW 251_ SAWVI 256_ LGAIS 261_ VYDLV 266_ AVLCP 271_ KGPLR 276_ MLVET 281_ AQERN 286_ EPIFP 291_ ALIYS 296_ SAMVW 301_ TVGMA 306_ KLDPS 311_ SQGAL 316_ QLPYD 321_ PEMEE 326_ DSYDS 331_ FGEPS 336_ YPEVF 341_ EPPLT 346_ GYPGE 351_ ELEEE 356_ EERGV 361_ KLGLG 366_ DFIFY 371_ SVLVG 376_ KAAAT 381_ GSGDW 386_ NTTLA 391_ CFVAI 396_ LIGLC 401_ LTLLL 406_ LAVFK 411_ KALPA 416_ LPISI 421_ TFGLI 426_ FYFST 431_ DNLVR 436_ PFMDT 441_LASHQ
1: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed:16959576). Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed:21285369)