Tuberin (Tuberous sclerosis 2 protein)
1_MAKPT 6_ SKDSG 11_ LKEKF 16_ KILLG 21_ LGTPR 26_ PNPRS 31_ AEGKQ 36_ TEFII 41_ TAEIL 46_ RELSM 51_ ECGLN 56_ NRIRM 61_ IGQIC 66_ EVAKT 71_ KKFEE 76_ HAVEA 81_ LWKAV 86_ ADLLQ 91_ PERPL 96_ EARHA 101_ VLALL 106_ KAIVQ 111_ GQGER 116_ LGVLR 121_ ALFFK 126_ VIKDY 131_ PSNED 136_ LHERL 141_ EVFKA 146_ LTDNG 151_ RHITY 156_ LEEEL 161_ ADFVL 166_ QWMDV 171_ GLSSE 176_ FLLVL 181_ VNLVK 186_ FNSCY 191_ LDEYI 196_ ARMVQ 201_ MICLL 206_ CVRTA 211_ SSVDI 216_ EVSLQ 221_ VLDAV 226_ VCYNC 231_ LPAES 236_ LPLFI 241_ VTLCR 246_ TINVK 251_ ELCEP 256_ CWKLM 261_ RNLLG 266_ THLGH 271_ SAIYN 276_ MCHLM 281_ EDRAY 286_ MEDAP 291_ LLRGA 296_ VFFVG 301_ MALWG 306_ AHRLY 311_ SLRNS 316_ PTSVL 321_ PSFYQ 326_ AMACP 331_ NEVVS 336_ YEIVL 341_ SITRL 346_ IKKYR 351_ KELQV 356_ VAWDI 361_ LLNII 366_ ERLLQ 371_ QLQTL 376_ DSPEL 381_ RTIVH 386_ DLLTT 391_ VEELC 396_ DQNEF 401_ HGSQE 406_ RYFEL 411_ VERCA 416_ DQRPE 421_ SSLLN 426_ LISYR 431_ AQSIH 436_ PAKDG 441_ WIQNL 446_ QALME 451_ RFFRS 456_ ESRGA 461_ VRIKV 466_ LDVLS 471_ FVLLI 476_ NRQFY 481_ EEELI 486_ NSVVI 491_ SQLSH 496_ IPEDK 501_ DHQVR 506_ KLATQ 511_ LLVDL 516_ AEGCH 521_ THHFN 526_ SLLDI 531_ IEKVM 536_ ARSLS 541_ PPPEL 546_ EERDV 551_ AAYSA 556_ SLEDV 561_ KTAVL 566_ GLLVI 571_ LQTKL 576_ YTLPA 581_ SHATR 586_ VYEML 591_ VSHIQ 596_ LHYKH 601_ SYTLP 606_ IASSI 611_ RLQAF 616_ DFLLL 621_ LRADS 626_ LHRLG 631_ LPNKD 636_ GVVRF 641_ SPYCV 646_ CDYME 651_ PERGS 656_ EKKTS 661_ GPLSP 666_ PTGPP 671_ GPAPA 676_ GPAVR 681_ LGSVP 686_ YSLLF 691_ RVLLQ 696_ CLKQE 701_ SDWKV 706_ LKLVL 711_ GRLPE 716_ SLRYK 721_ VLIFT 726_ SPCSV 731_ DQLCS 736_ ALCSM 741_ LSGPK 746_ TLERL 751_ RGAPE 756_ GFSRT 761_ DLHLA 766_ VVPVL 771_ TALIS 776_ YHNYL 781_ DKTKQ 786_ REMVY 791_ CLEQG 796_ LIHRC 801_ ASQCV 806_ VALSI 811_ CSVEM 816_ PDIII 821_ KALPV 826_ LVVKL 831_ THISA 836_ TASMA 841_ VPLLE 846_ FLSTL 851_ ARLPH 856_ LYRNF 861_ AAEQY 866_ ASVFA 871_ ISLPY 876_ TNPSK 881_ FNQYI 886_ VCLAH 891_ HVIAM 896_ WFIRC 901_ RLPFR 906_ KDFVP 911_ FITKG 916_ LRSNV 921_ LLSFD 926_ DTPEK 931_ DSFRA 936_ RSTSL 941_ NERPK 946_ SLRIA 951_ RPPKQ 956_ GLNNS 961_ PPVKE 966_ FKESS 971_ AAEAF 976_ RCRSI 981_ SVSEH 986_ VVRSR 991_ IQTSL 996_ TSASL 1001_ GSADE 1006_ NSVAQ 1011_ ADDSL 1016_ KNLHL 1021_ ELTET 1026_ CLDMM 1031_ ARYVF 1036_ SNFTA 1041_ VPKRS 1046_ PVGEF 1051_ LLAGG 1056_ RTKTW 1061_ LVGNK 1066_ LVTVT 1071_ TSVGT 1076_ GTRSL 1081_ LGLDS 1086_ GELQS 1091_ GPESS 1096_ SSPGV 1101_ HVRQT 1106_ KEAPA 1111_ KLESQ 1116_ AGQQV 1121_ SRGAR 1126_ DRVRS 1131_ MSGGH 1136_ GLRVG 1141_ ALDVP 1146_ ASQFL 1151_ GSATS 1156_ PGPRT 1161_ APAAK 1166_ PEKAS 1171_ AGTRV 1176_ PVQEK 1181_ TNLAA 1186_ YVPLL 1191_ TQGWA 1196_ EILVR 1201_ RPTGN 1206_ TSWLM 1211_ SLENP 1216_ LSPFS 1221_ SDINN 1226_ MPLQE 1231_ LSNAL 1236_ MAAER 1241_ FKEHR 1246_ DTALY 1251_ KSLSV 1256_ PAAST 1261_ AKPPP 1266_ LPRSN 1271_ TVASF 1276_ SSLYQ 1281_ SSCQG 1286_ QLHRS 1291_ VSWAD 1296_ SAVVM 1301_ EEGSP 1306_ GEVPV 1311_ LVEPP 1316_ GLEDV 1321_ EAALG 1326_ MDRRT 1331_ DAYSR 1336_ SSSVS 1341_ SQEEK 1346_ SLHAE 1351_ ELVGR 1356_ GIPIE 1361_ RVVSS 1366_ EGGRP 1371_ SVDLS 1376_ FQPSQ 1381_ PLSKS 1386_ SSSPE 1391_ LQTLQ 1396_ DILGD 1401_ PGDKA 1406_ DVGRL 1411_ SPEVK 1416_ ARSQS 1421_ GTLDG 1426_ ESAAW 1431_ SASGE 1436_ DSRGQ 1441_ PEGPL 1446_ PSSSP 1451_ RSPSG 1456_ LRPRG 1461_ YTISD 1466_ SAPSR 1471_ RGKRV 1476_ ERDAL 1481_ KSRAT 1486_ ASNAE 1491_ KVPGI 1496_ NPSFV 1501_ FLQLY 1506_ HSPFF 1511_ GDESN 1516_ KPILL 1521_ PNESQ 1526_ SFERS 1531_ VQLLD 1536_ QIPSY 1541_ DTHKI 1546_ AVLYV 1551_ GEGQS 1556_ NSELA 1561_ ILSNE 1566_ HGSYR 1571_ YTEFL 1576_ TGLGR 1581_ LIELK 1586_ DCQPD 1591_ KVYLG 1596_ GLDVC 1601_ GEDGQ 1606_ FTYCW 1611_ HDDIM 1616_ QAVFH 1621_ IATLM 1626_ PTKDV 1631_ DKHRC 1636_ DKKRH 1641_ LGNDF 1646_ VSIVY 1651_ NDSGE 1656_ DFKLG 1661_ TIKGQ 1666_ FNFVH 1671_ VIVTP 1676_ LDYEC 1681_ NLVSL 1686_ QCRKD 1691_ MEGLV 1696_ DTSVA 1701_ KIVSD 1706_ RNLPF 1711_ VARQM 1716_ ALHAN 1721_ MASQV 1726_ HHSRS 1731_ NPTDI 1736_ YPSKW 1741_ IARLR 1746_ HIKRL 1751_ RQRIC 1756_ EEAAY 1761_ SNPSL 1766_ PLVHP 1771_ PSHSK 1776_ APAQT 1781_ PAEPT 1786_ PGYEV 1791_ GQRKR 1796_ LISSV 1801_EDFTE
1: Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:33436626, PubMed:35772404). Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:12172553, PubMed:12820960, PubMed:12842888, PubMed:12906785, PubMed:15340059, PubMed:22819219, PubMed:24529379, PubMed:33436626). In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling (PubMed:12172553, PubMed:12271141, PubMed:12842888, PubMed:12906785, PubMed:22819219, PubMed:24529379, PubMed:28215400, PubMed:35772404). The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1 (PubMed:12172553, PubMed:24529379). Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling (By similarity). Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity)