Serine/threonine-protein kinase 19 (EC 2.7.11.1) (Protein G11) (Protein RP1)
1_MQKWF 6_ SAFDD 11_ AIIQR 16_ QWRAN 21_ PSRGG 26_ GGVSF 31_ TKEVD 36_ TNVAT 41_ GAPPR 46_ RQRVP 51_ GRACP 56_ WREPI 61_ RGRRG 66_ ARPGG 71_ GDAGG 76_ TPGET 81_ VRHCS 86_ APEDP 91_ IFRFS 96_ SLHSY 101_ PFPGT 106_ IKSRD 111_ MSWKR 116_ HHLIP 121_ ETFGV 126_ KRRRK 131_ RGPVE 136_ SDPLR 141_ GEPGS 146_ ARAAV 151_ SELMQ 156_ LFPRG 161_ LFEDA 166_ LPPIV 171_ LRSQV 176_ YSLVP 181_ DRTVA 186_ DRQLK 191_ ELQEQ 196_ GEIRI 201_ VQLGF 206_ DLDAH 211_ GIIFT 216_ EDYRT 221_ RVCDC 226_ VLKAC 231_ DGRPY 236_ AGAVQ 241_ KFLAS 246_ VLPAC 251_ GDLSF 256_ QQDQM 261_ TQTFG 266_ FRDSE 271_ ITHLV 276_ NAGVL 281_ TVRDA 286_ GSWWL 291_ AVPGA 296_ GRFIK 301_ YFVKG 306_ RQAVL 311_ SMVRK 316_ AKYRE 321_ LLLSE 326_ LLGRR 331_ APVVV 336_ RLGLT 341_ YHVHD 346_ LIGAQ 351_ LVDCI 356_ STTSG 361_TLLRL
1: DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER) (PubMed:38252411, PubMed:38890355, PubMed:39353615, PubMed:39547223, PubMed:39547228, PubMed:39547229). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions (PubMed:39547223, PubMed:39547228, PubMed:39547229). TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex (PubMed:39547228). WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair (PubMed:39353615, PubMed:39547228, PubMed:39547229). Directly interacts with RNAPII and also binds to downstream DNA (PubMed:39547229). Promotes the timely removal of DNA damage-stalled RNAPII, allowing downstream NER factors to access DNA lesions (PubMed:39547228, PubMed:39547229). Required for monoubiquitination of UVSSA (PubMed:39353615). Regulates repositioning and stabilization of UVSSA within the TC-NER complex (PubMed:39547223). Stimulates ubiquitination of RNAPII complex member RBP1 (PubMed:39547223). Also binds to RNA and regulates the expression levels of many mRNAs (PubMed:38252411, PubMed:38890355)