Transcription initiation factor TFIID subunit 6 (RNA polymerase II TBP-associated factor subunit E) (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII70) (Transcription initiation factor TFIID 80 kDa subunit) (TAF(II)80) (TAFII-80) (TAFII80)
1_MAEEK 6_ KLKLS 11_ NTVLP 16_ SESMK 21_ VVAES 26_ MGIAQ 31_ IQEET 36_ CQLLT 41_ DEVSY 46_ RIKEI 51_ AQDAL 56_ KFMHM 61_ GKRQK 66_ LTTSD 71_ IDYAL 76_ KLKNV 81_ EPLYG 86_ FHAQE 91_ FIPFR 96_ FASGG 101_ GRELY 106_ FYEEK 111_ EVDLS 116_ DIINT 121_ PLPRV 126_ PLDVC 131_ LKAHW 136_ LSIEG 141_ CQPAI 146_ PENPP 151_ PAPKE 156_ QQKAE 161_ ATEPL 166_ KSAKP 171_ GQEED 176_ GPLKG 181_ KGQGA 186_ TTADG 191_ KGKEK 196_ KAPPL 201_ LEGAP 206_ LRLKP 211_ RSIHE 216_ LSVEQ 221_ QLYYK 226_ EITEA 231_ CVGSC 236_ EAKRA 241_ EALQS 246_ IATDP 251_ GLYQM 256_ LPRFS 261_ TFISE 266_ GVRVN 271_ VVQNN 276_ LALLI 281_ YLMRM 286_ VKALM 291_ DNPTL 296_ YLEKY 301_ VHELI 306_ PAVMT 311_ CIVSR 316_ QLCLR 321_ PDVDN 326_ HWALR 331_ DFAAR 336_ LVAQI 341_ CKHFS 346_ TTTNN 351_ IQSRI 356_ TKTFT 361_ KSWVD 366_ EKTPW 371_ TTRYG 376_ SIAGL 381_ AELGH 386_ DVIKT 391_ LILPR 396_ LQQEG 401_ ERIRS 406_ VLDGP 411_ VLSNI 416_ DRIGA 421_ DHVQS 426_ LLLKH 431_ CAPVL 436_ AKLRP 441_ PPDNQ 446_ DAYRA 451_ EFGSL 456_ GPLLC 461_ SQVVK 466_ ARAQA 471_ ALQAQ 476_ QVNRT 481_ TLTIT 486_ QPRPT 491_ LTLSQ 496_ APQPG 501_ PRTPG 506_ LLKVP 511_ GSIAL 516_ PVQTL 521_ VSARA 526_ AAPPQ 531_ PSPPP 536_ TKFIV 541_ MSSSS 546_ SAPST 551_ QQVLS 556_ LSTSA 561_ PGSGS 566_ TTTSP 571_ VTTTV 576_ PSVQP 581_ IVKLV 586_ STATT 591_ APPST 596_ APSGP 601_ GSVQK 606_ YIVVS 611_ LPPTG 616_ EGKGG 621_ PTSHP 626_ SPVPP 631_ PASSP 636_ SPLSG 641_ SALCG 646_ GKQEA 651_ GDSPP 656_ PAPGT 661_ PKANG 666_ SQPNS 671_GSPQP
1: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C (PubMed:33795473). TAF6 homodimer connects TFIID modules, forming a rigid core (PubMed:33795473)
2: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700)