Kallikrein-7 (hK7) (EC 3.4.21.117) (Serine protease 6) (Stratum corneum chymotryptic enzyme) (hSCCE)
1_MARSL 6_ LLPLQ 11_ ILLLS 16_ LALET 21_ AGEEA 26_ QGDKI 31_ IDGAP 36_ CARGS 41_ HPWQV 46_ ALLSG 51_ NQLHC 56_ GGVLV 61_ NERWV 66_ LTAAH 71_ CKMNE 76_ YTVHL 81_ GSDTL 86_ GDRRA 91_ QRIKA 96_ SKSFR 101_ HPGYS 106_ TQTHV 111_ NDLML 116_ VKLNS 121_ QARLS 126_ SMVKK 131_ VRLPS 136_ RCEPP 141_ GTTCT 146_ VSGWG 151_ TTTSP 156_ DVTFP 161_ SDLMC 166_ VDVKL 171_ ISPQD 176_ CTKVY 181_ KDLLE 186_ NSMLC 191_ AGIPD 196_ SKKNA 201_ CNGDS 206_ GGPLV 211_ CRGTL 216_ QGLVS 221_ WGTFP 226_ CGQPN 231_ DPGVY 236_ TQVCK 241_ FTKWI 246_NDTMK
1: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines