Sulfotransferase 1E1 (ST1E1) (EC 2.8.2.4) (EST-1) (Estrogen sulfotransferase) (Sulfotransferase, estrogen-preferring)
1_MNSEL 6_ DYYEK 11_ FEEVH 16_ GILMY 21_ KDFVK 26_ YWDNV 31_ EAFQA 36_ RPDDL 41_ VIATY 46_ PKSGT 51_ TWVSE 56_ IVYMI 61_ YKEGD 66_ VEKCK 71_ EDVIF 76_ NRIPF 81_ LECRK 86_ ENLMN 91_ GVKQL 96_ DEMNS 101_ PRIVK 106_ THLPP 111_ ELLPA 116_ SFWEK 121_ DCKII 126_ YLCRN 131_ AKDVA 136_ VSFYY 141_ FFLMV 146_ AGHPN 151_ PGSFP 156_ EFVEK 161_ FMQGQ 166_ VPYGS 171_ WYKHV 176_ KSWWE 181_ KGKSP 186_ RVLFL 191_ FYEDL 196_ KEDIR 201_ KEVIK 206_ LIHFL 211_ ERKPS 216_ EELVD 221_ RIIHH 226_ TSFQE 231_ MKNNP 236_ STNYT 241_ TLPDE 246_ IMNQK 251_ LSPFM 256_ RKGIT 261_ GDWKN 266_ HFTVA 271_ LNEKF 276_ DKHYE 281_ QQMKE 286_STLKF
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:11006110, PubMed:11884392, PubMed:7779757). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency (PubMed:11006110, PubMed:19589875). Does not sulfonate cortisol, testosterone and dopamine (PubMed:11006110, PubMed:7779757). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system