Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase)
1_MGLPQ 6_ PGLWL 11_ KRLWV 16_ LLEVA 21_ VHVVV 26_ GKVLL 31_ ILFPD 36_ RVKRN 41_ ILAMG 46_ EKTGM 51_ TRNPH 56_ FSHDN 61_ WIPTF 66_ FSTQY 71_ FWFVL 76_ KVRWQ 81_ RLEDT 86_ TELGG 91_ LAPNC 96_ PVVRL 101_ SGQRC 106_ NIWEF 111_ MQGNR 116_ PLVLN 121_ FGSCT 126_ UPSFM 131_ FKFDQ 136_ FKRLI 141_ EDFSS 146_ IADFL 151_ VIYIE 156_ EAHAS 161_ DGWAF 166_ KNNMD 171_ IRNHQ 176_ NLQDR 181_ LQAAH 186_ LLLAR 191_ SPQCP 196_ VVVDT 201_ MQNQS 206_ SQLYA 211_ ALPER 216_ LYIIQ 221_ EGRIL 226_ YKGKS 231_ GPWNY 236_ NPEEV 241_RAVLE
1: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:12586771, PubMed:32718224, PubMed:18821722). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD) (PubMed:32718224, PubMed:18821722, PubMed:12586771, PubMed:18339710). Catalyzes the deiodination of T4 to 3,3',5'-triiodothyronine (rT3) via inner-ring deiodination (IRD) (PubMed:32718224). Catalyzes the deiodination of T3 to 3,3'-T2, 3,5-diiodothyronine (3,5-T2) to 3- monoiodothyronine (3-T1) and 3,3'-T2 to 3-T1 via IRD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'-diiodothyronamine (PubMed:18339710). Catalyzes the phenolic ring deiodination of 3,3'-diiodothyronamine and tyrosyl ring deiodinations of 3,5,3'-triiodothyronamine and 3,5-diiodothyronamine (By similarity). Catalyzes the deiodination of L-thyroxine sulfate and 3,3',5-triiodo-L-thyronine sulfate via IRD and of 3,3',5'-triiodo-L-thyronine sulfate via ORD (By similarity)