Gene name: MTHFS

Uniprot entry:

P49914

Protein names:

5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) (5,10-methenyl-tetrahydrofolate synthetase) (MTHFS) (Methenyl-THF synthetase)

Protein sequence:

1_MAAAA 6_ VSSAK 11_ RSLRG 16_ ELKQR 21_ LRAMS 26_ AEERL 31_ RQSRV 36_ LSQKV 41_ IAHSE 46_ YQKSK 51_ RISIF 56_ LSMQD 61_ EIETE 66_ EIIKD 71_ IFQRG 76_ KICFI 81_ PRYRF 86_ QSNHM 91_ DMVRI 96_ ESPEE 101_ ISLLP 106_ KTSWN 111_ IPQPG 116_ EGDVR 121_ EEALS 126_ TGGLD 131_ LIFMP 136_ GLGFD 141_ KHGNR 146_ LGRGK 151_ GYYDA 156_ YLKRC 161_ LQHQE 166_ VKPYT 171_ LALAF 176_ KEQIC 181_ LQVPV 186_ NENDM 191_ KVDEV 196_LYEDS

Protein annotations

Protein functions:

1: Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10-methenyltetrahydrofolate