DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)
1_MSLAF 6_ KIFFP 11_ QTLRA 16_ LSRKE 21_ LCLFR 26_ KHHWR 31_ DVRQF 36_ SQWSE 41_ TDLLH 46_ GHPLF 51_ LRRKP 56_ VLSFQ 61_ GSHLR 66_ SRATY 71_ LVFLP 76_ GLHVG 81_ LCSGP 86_ CEMAE 91_ QRFCV 96_ DYAKR 101_ GTAGC 106_ KKCKE 111_ KIVKG 116_ VCRIG 121_ KVVPN 126_ PFSES 131_ GGDMK 136_ EWYHI 141_ KCMFE 146_ KLERA 151_ RATTK 156_ KIEDL 161_ TELEG 166_ WEELE 171_ DNEKE 176_ QITQH 181_ IADLS 186_ SKAAG 191_ TPKKK 196_ AVVQA 201_ KLTTT 206_ GQVTS 211_ PVKGA 216_ SFVTS 221_ TNPRK 226_ FSGFS 231_ AKPNN 236_ SGEAP 241_ SSPTP 246_ KRSLS 251_ SSKCD 256_ PRHKD 261_ CLLRE 266_ FRKLC 271_ AMVAD 276_ NPSYN 281_ TKTQI 286_ IQDFL 291_ RKGSA 296_ GDGFH 301_ GDVYL 306_ TVKLL 311_ LPGVI 316_ KTVYN 321_ LNDKQ 326_ IVKLF 331_ SRIFN 336_ CNPDD 341_ MARDL 346_ EQGDV 351_ SETIR 356_ VFFEQ 361_ SKSFP 366_ PAAKS 371_ LLTIQ 376_ EVDEF 381_ LLRLS 386_ KLTKE 391_ DEQQQ 396_ ALQDI 401_ ASRCT 406_ ANDLK 411_ CIIRL 416_ IKHDL 421_ KMNSG 426_ AKHVL 431_ DALDP 436_ NAYEA 441_ FKASR 446_ NLQDV 451_ VERVL 456_ HNAQE 461_ VEKEP 466_ GQRRA 471_ LSVQA 476_ SLMTP 481_ VQPML 486_ AEACK 491_ SVEYA 496_ MKKCP 501_ NGMFS 506_ EIKYD 511_ GERVQ 516_ VHKNG 521_ DHFSY 526_ FSRSL 531_ KPVLP 536_ HKVAH 541_ FKDYI 546_ PQAFP 551_ GGHSM 556_ ILDSE 561_ VLLID 566_ NKTGK 571_ PLPFG 576_ TLGVH 581_ KKAAF 586_ QDANV 591_ CLFVF 596_ DCIYF 601_ NDVSL 606_ MDRPL 611_ CERRK 616_ FLHDN 621_ MVEIP 626_ NRIMF 631_ SEMKR 636_ VTKAL 641_ DLADM 646_ ITRVI 651_ QEGLE 656_ GLVLK 661_ DVKGT 666_ YEPGK 671_ RHWLK 676_ VKKDY 681_ LNEGA 686_ MADTA 691_ DLVVL 696_ GAFYG 701_ QGSKG 706_ GMMSI 711_ FLMGC 716_ YDPGS 721_ QKWCT 726_ VTKCA 731_ GGHDD 736_ ATLAR 741_ LQNEL 746_ DMVKI 751_ SKDPS 756_ KIPSW 761_ LKVNK 766_ IYYPD 771_ FIVPD 776_ PKKAA 781_ VWEIT 786_ GAEFS 791_ KSEAH 796_ TADGI 801_ SIRFP 806_ RCTRI 811_ RDDKD 816_ WKSAT 821_ NLPQL 826_ KELYQ 831_ LSKEK 836_ ADFTV 841_ VAGDE 846_ GSSTT 851_ GGSSE 856_ ENKGP 861_ SGSAV 866_ SRKAP 871_ SKPSA 876_ STKKA 881_ EGKLS 886_ NSNSK 891_ DGNMQ 896_ TAKPS 901_ AMKVG 906_ EKLAT 911_ KSSPV 916_ KVGEK 921_ RKAAD 926_ ETLCQ 931_ TKVLL 936_ DIFTG 941_ VRLYL 946_ PPSTP 951_ DFSRL 956_ RRYFV 961_ AFDGD 966_ LVQEF 971_ DMTSA 976_ THVLG 981_ SRDKN 986_ PAAQQ 991_ VSPEW 996_ IWACI 1001_RKRRL
1: Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627)