Cyclin-dependent kinase inhibitor 1C (Cyclin-dependent kinase inhibitor p57) (p57Kip2)
1_MSDAS 6_ LRSTS 11_ TMERL 16_ VARGT 21_ FPVLV 26_ RTSAC 31_ RSLFG 36_ PVDHE 41_ ELSRE 46_ LQARL 51_ AELNA 56_ EDQNR 61_ WDYDF 66_ QQDMP 71_ LRGPG 76_ RLQWT 81_ EVDSD 86_ SVPAF 91_ YRETV 96_ QVGRC 101_ RLLLA 106_ PRPVA 111_ VAVAV 116_ SPPLE 121_ PAAES 126_ LDGLE 131_ EAPEQ 136_ LPSVP 141_ VPAPA 146_ STPPP 151_ VPVLA 156_ PAPAP 161_ APAPV 166_ AAPVA 171_ APVAV 176_ AVLAP 181_ APAPA 186_ PAPAP 191_ APAPV 196_ AAPAP 201_ APAPA 206_ PAPAP 211_ APAPA 216_ PDAAP 221_ QESAE 226_ QGANQ 231_ GQRGQ 236_ EPLAD 241_ QLHSG 246_ ISGRP 251_ AAGTA 256_ AASAN 261_ GAAIK 266_ KLSGP 271_ LISDF 276_ FAKRK 281_ RSAPE 286_ KSSGD 291_ VPAPC 296_ PSPSA 301_ APGVG 306_ SVEQT 311_PRKRL
1: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life