Guanine nucleotide-binding protein G(q) subunit alpha (Guanine nucleotide-binding protein alpha-q)
1_MTLES 6_ IMACC 11_ LSEEA 16_ KEARR 21_ INDEI 26_ ERQLR 31_ RDKRD 36_ ARREL 41_ KLLLL 46_ GTGES 51_ GKSTF 56_ IKQMR 61_ IIHGS 66_ GYSDE 71_ DKRGF 76_ TKLVY 81_ QNIFT 86_ AMQAM 91_ IRAMD 96_ TLKIP 101_ YKYEH 106_ NKAHA 111_ QLVRE 116_ VDVEK 121_ VSAFE 126_ NPYVD 131_ AIKSL 136_ WNDPG 141_ IQECY 146_ DRRRE 151_ YQLSD 156_ STKYY 161_ LNDLD 166_ RVADP 171_ AYLPT 176_ QQDVL 181_ RVRVP 186_ TTGII 191_ EYPFD 196_ LQSVI 201_ FRMVD 206_ VGGQR 211_ SERRK 216_ WIHCF 221_ ENVTS 226_ IMFLV 231_ ALSEY 236_ DQVLV 241_ ESDNE 246_ NRMEE 251_ SKALF 256_ RTIIT 261_ YPWFQ 266_ NSSVI 271_ LFLNK 276_ KDLLE 281_ EKIMY 286_ SHLVD 291_ YFPEY 296_ DGPQR 301_ DAQAA 306_ REFIL 311_ KMFVD 316_ LNPDS 321_ DKIIY 326_ SHFTC 331_ ATDTE 336_ NIRFV 341_ FAAVK 346_ DTILQ 351_LNLKE
1: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:37991948). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:37991948). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:37991948). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:37991948). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:37991948). Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNAQ activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:37991948). Required for platelet activation (By similarity). Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity (By similarity). Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNA11, required for heart development (By similarity)