Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)
1_MAGPA 6_ WISKV 11_ SRLLG 16_ AFHNP 21_ KQVTR 26_ GFTGG 31_ VQTVT 36_ LIPGD 41_ GIGPE 46_ ISAAV 51_ MKIFD 56_ AAKAP 61_ IQWEE 66_ RNVTA 71_ IQGPG 76_ GKWMI 81_ PSEAK 86_ ESMDK 91_ NKMGL 96_ KGPLK 101_ TPIAA 106_ GHPSM 111_ NLLLR 116_ KTFDL 121_ YANVR 126_ PCVSI 131_ EGYKT 136_ PYTDV 141_ NIVTI 146_ RENTE 151_ GEYSG 156_ IEHVI 161_ VDGVV 166_ QSIKL 171_ ITEGA 176_ SKRIA 181_ EFAFE 186_ YARNN 191_ HRSNV 196_ TAVHK 201_ ANIMR 206_ MSDGL 211_ FLQKC 216_ REVAE 221_ SCKDI 226_ KFNEM 231_ YLDTV 236_ CLNMV 241_ QDPSQ 246_ FDVLV 251_ MPNLY 256_ GDILS 261_ DLCAG 266_ LIGGL 271_ GVTPS 276_ GNIGA 281_ NGVAI 286_ FESVH 291_ GTAPD 296_ IAGKD 301_ MANPT 306_ ALLLS 311_ AVMML 316_ RHMGL 321_ FDHAA 326_ RIEAA 331_ CFATI 336_ KDGKS 341_ LTKDL 346_ GGNAK 351_ CSDFT 356_ EEICR 361_RVKDL
1: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers