Motor neuron and pancreas homeobox protein 1 (Homeobox protein HB9)
1_MEKSK 6_ NFRID 11_ ALLAV 16_ DPPRA 21_ ASAQS 26_ APLAL 31_ VTSLA 36_ AAASG 41_ TGGGG 46_ GGGGA 51_ SGGTS 56_ GSCSP 61_ ASSEP 66_ PAAPA 71_ DRLRA 76_ ESPSP 81_ PRLLA 86_ AHCAL 91_ LPKPG 96_ FLGAG 101_ GGGGG 106_ TGGGH 111_ GGPHH 116_ HAHPG 121_ AAAAA 126_ AAAAA 131_ AAAAG 136_ GLALG 141_ LHPGG 146_ AQGGA 151_ GLPAQ 156_ AALYG 161_ HPVYG 166_ YSAAA 171_ AAAAL 176_ AGQHP 181_ ALSYS 186_ YPQVQ 191_ GAHPA 196_ HPADP 201_ IKLGA 206_ GTFQL 211_ DQWLR 216_ ASTAG 221_ MILPK 226_ MPDFN 231_ SQAQS 236_ NLLGK 241_ CRRPR 246_ TAFTS 251_ QQLLE 256_ LEHQF 261_ KLNKY 266_ LSRPK 271_ RFEVA 276_ TSLML 281_ TETQV 286_ KIWFQ 291_ NRRMK 296_ WKRSK 301_ KAKEQ 306_ AAQEA 311_ EKQKG 316_ GGGGA 321_ GKGGA 326_ EEPGA 331_ EELLG 336_ PPAPG 341_ DKGSG 346_ RRLRD 351_ LRDSD 356_ PEEDE 361_ DEDDE 366_ DHFPY 371_ SNGAS 376_ VHAAS 381_ SDCSS 386_ EDDSP 391_ PPRPS 396_HQPAP
1: Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity)