Homeobox protein MOX-1 (Mesenchyme homeobox 1)
1_MDPAA 6_ SSCMR 11_ SLQPP 16_ APVWG 21_ CLRNP 26_ HSEGN 31_ GASGL 36_ PHYPP 41_ TPFSF 46_ HQKPD 51_ FLATA 56_ TAAYP 61_ DFSAS 66_ CLAAT 71_ PHSLP 76_ QEEHI 81_ FTEQH 86_ PAFPQ 91_ SPNWH 96_ FPVSD 101_ ARRRP 106_ NSGPA 111_ GGSKE 116_ MGTSS 121_ LGLVD 126_ TTGGP 131_ GDDYG 136_ VLGST 141_ ANETE 146_ KKSSR 151_ RRKES 156_ SDNQE 161_ NRGKP 166_ EGSSK 171_ ARKER 176_ TAFTK 181_ EQLRE 186_ LEAEF 191_ AHHNY 196_ LTRLR 201_ RYEIA 206_ VNLDL 211_ SERQV 216_ KVWFQ 221_ NRRMK 226_ WKRVK 231_ GGQPI 236_ SPNGQ 241_ DPEDG 246_DSTAS
1: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome