Homeobox protein MOX-2 (Growth arrest-specific homeobox) (Mesenchyme homeobox 2)
1_MEHPL 6_ FGCLR 11_ SPHAT 16_ AQGLH 21_ PFSQS 26_ SLALH 31_ GRSDH 36_ MSYPE 41_ LSTSS 46_ SSCII 51_ AGYPN 56_ EEGMF 61_ ASQHH 66_ RGHHH 71_ HHHHH 76_ HHHHH 81_ QQQQH 86_ QALQT 91_ NWHLP 96_ QMSSP 101_ PSAAR 106_ HSLCL 111_ QPDSG 116_ GPPEL 121_ GSSPP 126_ VLCSN 131_ SSSLG 136_ SSTPT 141_ GAACA 146_ PGDYG 151_ RQALS 156_ PAEAE 161_ KRSGG 166_ KRKSD 171_ SSDSQ 176_ EGNYK 181_ SEVNS 186_ KPRKE 191_ RTAFT 196_ KEQIR 201_ ELEAE 206_ FAHHN 211_ YLTRL 216_ RRYEI 221_ AVNLD 226_ LTERQ 231_ VKVWF 236_ QNRRM 241_ KWKRV 246_ KGGQQ 251_ GAAAR 256_ EKELV 261_ NVKKG 266_ TLLPS 271_ ELSGI 276_ GAATL 281_ QQTGD 286_ SIANE 291_ DSHDS 296_DHSSE
1: Mesodermal transcription factor that plays a key role in somitogenesis and somitogenesis and limb muscle differentiation (By similarity). Required during limb development for normal appendicular muscle formation and for the normal regulation of myogenic genes (By similarity). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle (By similarity). Also acts as a negative regulator of angiogenesis (PubMed:17074759, PubMed:20516212, PubMed:22206000). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation (PubMed:17074759, PubMed:22206000). While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Together with TCF15, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells (By similarity)