Sulfotransferase 1A1 (ST1A1) (EC 2.8.2.1) (Aryl sulfotransferase 1) (HAST1/HAST2) (Phenol sulfotransferase 1) (Phenol-sulfating phenol sulfotransferase 1) (P-PST 1) (ST1A3) (Thermostable phenol sulfotransferase) (Ts-PST)
1_MELIQ 6_ DTSRP 11_ PLEYV 16_ KGVPL 21_ IKYFA 26_ EALGP 31_ LQSFQ 36_ ARPDD 41_ LLIST 46_ YPKSG 51_ TTWVS 56_ QILDM 61_ IYQGG 66_ DLEKC 71_ HRAPI 76_ FMRVP 81_ FLEFK 86_ APGIP 91_ SGMET 96_ LKDTP 101_ APRLL 106_ KTHLP 111_ LALLP 116_ QTLLD 121_ QKVKV 126_ VYVAR 131_ NAKDV 136_ AVSYY 141_ HFYHM 146_ AKVHP 151_ EPGTW 156_ DSFLE 161_ KFMVG 166_ EVSYG 171_ SWYQH 176_ VQEWW 181_ ELSRT 186_ HPVLY 191_ LFYED 196_ MKENP 201_ KREIQ 206_ KILEF 211_ VGRSL 216_ PEETV 221_ DFVVQ 226_ HTSFK 231_ EMKKN 236_ PMTNY 241_ TTVPQ 246_ EFMDH 251_ SISPF 256_ MRKGM 261_ AGDWK 266_ TTFTV 271_ AQNER 276_ FDADY 281_ AEKMA 286_GCSLS
1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones (PubMed:12471039, PubMed:16221673, PubMed:21723874, PubMed:22069470, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). Catalyzes the sulfate conjugation of dopamine (PubMed:8093002). Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (PubMed:10199779)