Matrix metalloproteinase-14 (MMP-14) (EC 3.4.24.80) (MMP-X1) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP)
1_MSPAP 6_ RPPRC 11_ LLLPL 16_ LTLGT 21_ ALASL 26_ GSAQS 31_ SSFSP 36_ EAWLQ 41_ QYGYL 46_ PPGDL 51_ RTHTQ 56_ RSPQS 61_ LSAAI 66_ AAMQK 71_ FYGLQ 76_ VTGKA 81_ DADTM 86_ KAMRR 91_ PRCGV 96_ PDKFG 101_ AEIKA 106_ NVRRK 111_ RYAIQ 116_ GLKWQ 121_ HNEIT 126_ FCIQN 131_ YTPKV 136_ GEYAT 141_ YEAIR 146_ KAFRV 151_ WESAT 156_ PLRFR 161_ EVPYA 166_ YIREG 171_ HEKQA 176_ DIMIF 181_ FAEGF 186_ HGDST 191_ PFDGE 196_ GGFLA 201_ HAYFP 206_ GPNIG 211_ GDTHF 216_ DSAEP 221_ WTVRN 226_ EDLNG 231_ NDIFL 236_ VAVHE 241_ LGHAL 246_ GLEHS 251_ SDPSA 256_ IMAPF 261_ YQWMD 266_ TENFV 271_ LPDDD 276_ RRGIQ 281_ QLYGG 286_ ESGFP 291_ TKMPP 296_ QPRTT 301_ SRPSV 306_ PDKPK 311_ NPTYG 316_ PNICD 321_ GNFDT 326_ VAMLR 331_ GEMFV 336_ FKERW 341_ FWRVR 346_ NNQVM 351_ DGYPM 356_ PIGQF 361_ WRGLP 366_ ASINT 371_ AYERK 376_ DGKFV 381_ FFKGD 386_ KHWVF 391_ DEASL 396_ EPGYP 401_ KHIKE 406_ LGRGL 411_ PTDKI 416_ DAALF 421_ WMPNG 426_ KTYFF 431_ RGNKY 436_ YRFNE 441_ ELRAV 446_ DSEYP 451_ KNIKV 456_ WEGIP 461_ ESPRG 466_ SFMGS 471_ DEVFT 476_ YFYKG 481_ NKYWK 486_ FNNQK 491_ LKVEP 496_ GYPKS 501_ ALRDW 506_ MGCPS 511_ GGRPD 516_ EGTEE 521_ ETEVI 526_ IIEVD 531_ EEGGG 536_ AVSAA 541_ AVVLP 546_ VLLLL 551_ LVLAV 556_ GLAVF 561_ FFRRH 566_ GTPRR 571_ LLYCQ 576_RSLLD
1: Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed:8015608). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration (PubMed:22065321, PubMed:8015608). Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657, PubMed:22065321). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1 (PubMed:21572390). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (PubMed:35177851)