Emerin
1_MDNYA 6_ DLSDT 11_ ELTTL 16_ LRRYN 21_ IPHGP 26_ VVGST 31_ RRLYE 36_ KKIFE 41_ YETQR 46_ RRLSP 51_ PSSSA 56_ ASSYS 61_ FSDLN 66_ STRGD 71_ ADMYD 76_ LPKKE 81_ DALLY 86_ QSKGY 91_ NDDYY 96_ EESYF 101_ TTRTY 106_ GEPES 111_ AGPSR 116_ AVRQS 121_ VTSFP 126_ DADAF 131_ HHQVH 136_ DDDLL 141_ SSSEE 146_ ECKDR 151_ ERPMY 156_ GRDSA 161_ YQSIT 166_ HYRPV 171_ SASRS 176_ SLDLS 181_ YYPTS 186_ SSTSF 191_ MSSSS 196_ SSSSW 201_ LTRRA 206_ IRPEN 211_ RAPGA 216_ GLGQD 221_ RQVPL 226_ WGQLL 231_ LFLVF 236_ VIVLF 241_ FIYHF 246_MQAEE
1: Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD