5-hydroxytryptamine receptor 6 (5-HT-6) (5-HT6) (Serotonin receptor 6)
1_MVPEP 6_ GPTAN 11_ STPAW 16_ GAGPP 21_ SAPGG 26_ SGWVA 31_ AALCV 36_ VIALT 41_ AAANS 46_ LLIAL 51_ ICTQP 56_ ALRNT 61_ SNFFL 66_ VSLFT 71_ SDLMV 76_ GLVVM 81_ PPAML 86_ NALYG 91_ RWVLA 96_ RGLCL 101_ LWTAF 106_ DVMCC 111_ SASIL 116_ NLCLI 121_ SLDRY 126_ LLILS 131_ PLRYK 136_ LRMTP 141_ LRALA 146_ LVLGA 151_ WSLAA 156_ LASFL 161_ PLLLG 166_ WHELG 171_ HARPP 176_ VPGQC 181_ RLLAS 186_ LPFVL 191_ VASGL 196_ TFFLP 201_ SGAIC 206_ FTYCR 211_ ILLAA 216_ RKQAV 221_ QVASL 226_ TTGMA 231_ SQASE 236_ TLQVP 241_ RTPRP 246_ GVESA 251_ DSRRL 256_ ATKHS 261_ RKALK 266_ ASLTL 271_ GILLG 276_ MFFVT 281_ WLPFF 286_ VANIV 291_ QAVCD 296_ CISPG 301_ LFDVL 306_ TWLGY 311_ CNSTM 316_ NPIIY 321_ PLFMR 326_ DFKRA 331_ LGRFL 336_ PCPRC 341_ PRERQ 346_ ASLAS 351_ PSLRT 356_ SHSGP 361_ RPGLS 366_ LQQVL 371_ PLPLP 376_ PDSDS 381_ DSDAG 386_ SGGSS 391_ GLRLT 396_ AQLLL 401_ PGEAT 406_ QDPPL 411_ PTRAA 416_ AAVNF 421_ FNIDP 426_ AEPEL 431_RPHPL
1: G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:36989299, PubMed:37327704, PubMed:8522988). Also has a high affinity for tricyclic psychotropic drugs (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614). HTR6 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614, PubMed:37327704). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of mTOR signaling (PubMed:23027611)