Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)
1_MSSES 6_ KEQHN 11_ VSPRD 16_ SAEGN 21_ DSYPS 26_ GIHLE 31_ LQRES 36_ STDFK 41_ QFETN 46_ DQCRP 51_ YHRIL 56_ IERQE 61_ KSDTN 66_ FKEFV 71_ IKKLQ 76_ KNCQC 81_ SPAKA 86_ KNMIL 91_ GFLPV 96_ LQWLP 101_ KYDLK 106_ KNILG 111_ DVMSG 116_ LIVGI 121_ LLVPQ 126_ SIAYS 131_ LLAGQ 136_ EPVYG 141_ LYTSF 146_ FASII 151_ YFLLG 156_ TSRHI 161_ SVGIF 166_ GVLCL 171_ MIGET 176_ VDREL 181_ QKAGY 186_ DNAHS 191_ APSLG 196_ MVSNG 201_ STLLN 206_ HTSDR 211_ ICDKS 216_ CYAIM 221_ VGSTV 226_ TFIAG 231_ VYQVA 236_ MGFFQ 241_ VGFVS 246_ VYLSD 251_ ALLSG 256_ FVTGA 261_ SFTIL 266_ TSQAK 271_ YLLGL 276_ NLPRT 281_ NGVGS 286_ LITTW 291_ IHVFR 296_ NIHKT 301_ NLCDL 306_ ITSLL 311_ CLLVL 316_ LPTKE 321_ LNEHF 326_ KSKLK 331_ APIPI 336_ ELVVV 341_ VAATL 346_ ASHFG 351_ KLHEN 356_ YNSSI 361_ AGHIP 366_ TGFMP 371_ PKVPE 376_ WNLIP 381_ SVAVD 386_ AIAIS 391_ IIGFA 396_ ITVSL 401_ SEMFA 406_ KKHGY 411_ TVKAN 416_ QEMYA 421_ IGFCN 426_ IIPSF 431_ FHCFT 436_ TSAAL 441_ AKTLV 446_ KESTG 451_ CHTQL 456_ SGVVT 461_ ALVLL 466_ LVLLV 471_ IAPLF 476_ YSLQK 481_ SVLGV 486_ ITIVN 491_ LRGAL 496_ RKFRD 501_ LPKMW 506_ SISRM 511_ DTVIW 516_ FVTML 521_ SSALL 526_ STEIG 531_ LLVGV 536_ CFSIF 541_ CVILR 546_ TQKPK 551_ SSLLG 556_ LVEES 561_ EVFES 566_ VSAYK 571_ NLQIK 576_ PGIKI 581_ FRFVA 586_ PLYYI 591_ NKECF 596_ KSALY 601_ KQTVN 606_ PILIK 611_ VAWKK 616_ AAKRK 621_ IKEKV 626_ VTLGG 631_ IQDEM 636_ SVQLS 641_ HDPLE 646_ LHTIV 651_ IDCSA 656_ IQFLD 661_ TAGIH 666_ TLKEV 671_ RRDYE 676_ AIGIQ 681_ VLLAQ 686_ CNPTV 691_ RDSLT 696_ NGEYC 701_ KKEEE 706_ NLLFY 711_ SVYEA 716_ MAFAE 721_ VSKNQ 726_ KGVCV 731_PNGLS
1: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:11448940, PubMed:15294877, PubMed:20219950, PubMed:7923357). Mediates electroneutral anion exchange of sulfate ions for oxalate ions and of sulfate and oxalate ions for chloride ions (PubMed:20219950). Mediates exchange of sulfate and oxalate ions for hydroxyl ions and of chloride ions for bromide, iodide and nitrate ions (By similarity). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (By similarity). Essential for chondrocyte proliferation, differentiation and cell size expansion (By similarity)