Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1)
1_MAMRE 6_ LVEAE 11_ CGGAN 16_ PLMKL 21_ AGHFT 26_ QDKAL 31_ RQEGL 36_ RPGPW 41_ PPGAP 46_ ASEAA 51_ SKPLG 56_ VASED 61_ ELVAE 66_ FLQDQ 71_ NAPLV 76_ SRAPQ 81_ TFKMD 86_ DLLAE 91_ MQQIE 96_ QSNFR 101_ QAPQR 106_ APGVA 111_ DLALS 116_ ENWAQ 121_ EFLAA 126_ GDAVD 131_ VTQDY 136_ NETDW 141_ SQEFI 146_ SEVTD 151_ PLSVS 156_ PARWA 161_ EEYLE 166_ QSEEK 171_ LWLGE 176_ PEGTA 181_ TDRWY 186_ DEYHP 191_ EEDLQ 196_ HTASD 201_ FVAKV 206_ DDPKL 211_ ANSEF 216_ LKFVR 221_ QIGEG 226_ QVSLE 231_ SGAGS 236_ GRAQA 241_ EQWAA 246_ EFIQQ 251_ QGTSD 256_ AWVDQ 261_ FTRPV 266_ NTSAL 271_ DMEFE 276_ RAKSA 281_ IESDV 286_ DFWDK 291_ LQAEL 296_ EEMAK 301_ RDAEA 306_ HPWLS 311_ DYDDL 316_ TSATY 321_ DKGYQ 326_ FEEEN 331_ PLRDH 336_ PQPFE 341_ EGLRR 346_ LQEGD 351_ LPNAV 356_ LLFEA 361_ AVQQD 366_ PKHME 371_ AWQYL 376_ GTTQA 381_ ENEQE 386_ LLAIS 391_ ALRRC 396_ LELKP 401_ DNQTA 406_ LMALA 411_ VSFTN 416_ ESLQR 421_ QACET 426_ LRDWL 431_ RYTPA 436_ YAHLV 441_ TPAEE 446_ GAGGA 451_ GLGPS 456_ KRILG 461_ SLLSD 466_ SLFLE 471_ VKELF 476_ LAAVR 481_ LDPTS 486_ IDPDV 491_ QCGLG 496_ VLFNL 501_ SGEYD 506_ KAVDC 511_ FTAAL 516_ SVRPN 521_ DYLLW 526_ NKLGA 531_ TLANG 536_ NQSEE 541_ AVAAY 546_ RRALE 551_ LQPGY 556_ IRSRY 561_ NLGIS 566_ CINLG 571_ AHREA 576_ VEHFL 581_ EALNM 586_ QRKSR 591_ GPRGE 596_ GGAMS 601_ ENIWS 606_ TLRLA 611_ LSMLG 616_ QSDAY 621_ GAADA 626_ RDLST 631_LLTMF
1: Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) (PubMed:11101887, PubMed:11336669, PubMed:12456682, PubMed:16314507, PubMed:17157249, PubMed:17428317, PubMed:21976670, PubMed:26344566, PubMed:7706321, PubMed:7719337, PubMed:7790377). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins (PubMed:12456682, PubMed:17157249, PubMed:21976670, PubMed:26344566). PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle (PubMed:11336669, PubMed:24662292)
2: In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (PubMed:11336669, PubMed:11546814, PubMed:25538232, PubMed:33389129, PubMed:9668159). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (PubMed:25538232). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5 (PubMed:25538232)
3: Does not mediate translocation of peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal