Vasodilator-stimulated phosphoprotein (VASP)
1_MSETV 6_ ICSSR 11_ ATVML 16_ YDDGN 21_ KRWLP 26_ AGTGP 31_ QAFSR 36_ VQIYH 41_ NPTAN 46_ SFRVV 51_ GRKMQ 56_ PDQQV 61_ VINCA 66_ IVRGV 71_ KYNQA 76_ TPNFH 81_ QWRDA 86_ RQVWG 91_ LNFGS 96_ KEDAA 101_ QFAAG 106_ MASAL 111_ EALEG 116_ GGPPP 121_ PPALP 126_ TWSVP 131_ NGPSP 136_ EEVEQ 141_ QKRQQ 146_ PGPSE 151_ HIERR 156_ VSNAG 161_ GPPAP 166_ PAGGP 171_ PPPPG 176_ PPPPP 181_ GPPPP 186_ PGLPP 191_ SGVPA 196_ AAHGA 201_ GGGPP 206_ PAPPL 211_ PAAQG 216_ PGGGG 221_ AGAPG 226_ LAAAI 231_ AGAKL 236_ RKVSK 241_ QEEAS 246_ GGPTA 251_ PKAES 256_ GRSGG 261_ GGLME 266_ EMNAM 271_ LARRR 276_ KATQV 281_ GEKTP 286_ KDESA 291_ NQEEP 296_ EARVP 301_ AQSES 306_ VRRPW 311_ EKNST 316_ TLPRM 321_ KSSSS 326_ VTTSE 331_ TQPCT 336_ PSSSD 341_ YSDLQ 346_ RVKQE 351_ LLEEV 356_ KKELQ 361_ KVKEE 366_ IIEAF 371_VQELR
1: Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation