Dynamin-2 (EC 3.6.5.5)
1_MGNRG 6_ MEELI 11_ PLVNK 16_ LQDAF 21_ SSIGQ 26_ SCHLD 31_ LPQIA 36_ VVGGQ 41_ SAGKS 46_ SVLEN 51_ FVGRD 56_ FLPRG 61_ SGIVT 66_ RRPLI 71_ LQLIF 76_ SKTEH 81_ AEFLH 86_ CKSKK 91_ FTDFD 96_ EVRQE 101_ IEAET 106_ DRVTG 111_ TNKGI 116_ SPVPI 121_ NLRVY 126_ SPHVL 131_ NLTLI 136_ DLPGI 141_ TKVPV 146_ GDQPP 151_ DIEYQ 156_ IKDMI 161_ LQFIS 166_ RESSL 171_ ILAVT 176_ PANMD 181_ LANSD 186_ ALKLA 191_ KEVDP 196_ QGLRT 201_ IGVIT 206_ KLDLM 211_ DEGTD 216_ ARDVL 221_ ENKLL 226_ PLRRG 231_ YIGVV 236_ NRSQK 241_ DIEGK 246_ KDIRA 251_ ALAAE 256_ RKFFL 261_ SHPAY 266_ RHMAD 271_ RMGTP 276_ HLQKT 281_ LNQQL 286_ TNHIR 291_ ESLPA 296_ LRSKL 301_ QSQLL 306_ SLEKE 311_ VEEYK 316_ NFRPD 321_ DPTRK 326_ TKALL 331_ QMVQQ 336_ FGVDF 341_ EKRIE 346_ GSGDQ 351_ VDTLE 356_ LSGGA 361_ RINRI 366_ FHERF 371_ PFELV 376_ KMEFD 381_ EKDLR 386_ REISY 391_ AIKNI 396_ HGVRT 401_ GLFTP 406_ DLAFE 411_ AIVKK 416_ QVVKL 421_ KEPCL 426_ KCVDL 431_ VIQEL 436_ INTVR 441_ QCTSK 446_ LSSYP 451_ RLREE 456_ TERIV 461_ TTYIR 466_ EREGR 471_ TKDQI 476_ LLLID 481_ IEQSY 486_ INTNH 491_ EDFIG 496_ FANAQ 501_ QRSTQ 506_ LNKKR 511_ AIPNQ 516_ GEILV 521_ IRRGW 526_ LTINN 531_ ISLMK 536_ GGSKE 541_ YWFVL 546_ TAESL 551_ SWYKD 556_ EEEKE 561_ KKYML 566_ PLDNL 571_ KIRDV 576_ EKGFM 581_ SNKHV 586_ FAIFN 591_ TEQRN 596_ VYKDL 601_ RQIEL 606_ ACDSQ 611_ EDVDS 616_ WKASF 621_ LRAGV 626_ YPEKD 631_ QAENE 636_ DGAQE 641_ NTFSM 646_ DPQLE 651_ RQVET 656_ IRNLV 661_ DSYVA 666_ IINKS 671_ IRDLM 676_ PKTIM 681_ HLMIN 686_ NTKAF 691_ IHHEL 696_ LAYLY 701_ SSADQ 706_ SSLME 711_ ESADQ 716_ AQRRD 721_ DMLRM 726_ YHALK 731_ EALNI 736_ IGDIS 741_ TSTVS 746_ TPVPP 751_ PVDDT 756_ WLQSA 761_ SSHSP 766_ TPQRR 771_ PVSSI 776_ HPPGR 781_ PPAVR 786_ GPTPG 791_ PPLIP 796_ VPVGA 801_ AASFS 806_ APPIP 811_ SRPGP 816_ QSVFA 821_ NSDLF 826_ PAPPQ 831_ IPSRP 836_ VRIPP 841_ GIPPG 846_ VPSRR 851_ PPAAP 856_ SRPTI 861_IRPAE
1: Catalyzes the hydrolysis of GTP and utilizes this energy to mediate vesicle scission at plasma membrane during endocytosis and filament remodeling at many actin structures during organization of the actin cytoskeleton (PubMed:15731758, PubMed:19605363, PubMed:19623537, PubMed:33713620, PubMed:34744632). Plays an important role in vesicular trafficking processes, namely clathrin-mediated endocytosis (CME), exocytic and clathrin-coated vesicle from the trans-Golgi network, and PDGF stimulated macropinocytosis (PubMed:15731758, PubMed:19623537, PubMed:33713620). During vesicular trafficking process, associates to the membrane, through lipid binding, and self-assembles into ring-like structure through oligomerization to form a helical polymer around the vesicle membrane and leading to vesicle scission (PubMed:17636067, PubMed:34744632, PubMed:36445308). Plays a role in organization of the actin cytoskeleton by mediating arrangement of stress fibers and actin bundles in podocytes (By similarity). During organization of the actin cytoskeleton, self-assembles into ring-like structure that directly bundles actin filaments to form typical membrane tubules decorated with dynamin spiral polymers (By similarity). Self-assembly increases GTPase activity and the GTP hydrolysis causes the rapid depolymerization of dynamin spiral polymers, and results in dispersion of actin bundles (By similarity). Remodels, through its interaction with CTTN, bundled actin filaments in a GTPase-dependent manner and plays a role in orchestrating the global actomyosin cytoskeleton (PubMed:19605363). The interaction with CTTN stabilizes the interaction of DNM2 and actin filaments and stimulates the intrinsic GTPase activity that results in actin filament-barbed ends and increases the sensitivity of filaments in bundles to the actin depolymerizing factor, CFL1 (By similarity). Plays a role in the autophagy process, by participating in the formation of ATG9A vesicles destined for the autophagosomes through its interaction with SNX18 (PubMed:29437695), by mediating recycling endosome scission leading to autophagosome release through MAP1LC3B interaction (PubMed:29437695, PubMed:32315611). Also regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Also plays a role in cytokinesis (By similarity). May participate in centrosome cohesion through its interaction with TUBG1 (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Involved in membrane tubulation (PubMed:24135484)