Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M)
1_MAGVE 6_ EVAAS 11_ GSHLN 16_ GDLDP 21_ DDREE 26_ GAAST 31_ AEEAA 36_ KKKRR 41_ KKKKS 46_ KGPSA 51_ AGEQE 56_ PDKES 61_ GASVD 66_ EVARQ 71_ LERSA 76_ LEDKE 81_ RDEDD 86_ EDGDG 91_ DGDGA 96_ TGKKK 101_ KKKKK 106_ KRGPK 111_ VQTDP 116_ PSVPI 121_ CDLYP 126_ NGVFP 131_ KGQEC 136_ EYPPT 141_ QDGRT 146_ AAWRT 151_ TSEEK 156_ KALDQ 161_ ASEEI 166_ WNDFR 171_ EAAEA 176_ HRQVR 181_ KYVMS 186_ WIKPG 191_ MTMIE 196_ ICEKL 201_ EDCSR 206_ KLIKE 211_ NGLNA 216_ GLAFP 221_ TGCSL 226_ NNCAA 231_ HYTPN 236_ AGDTT 241_ VLQYD 246_ DICKI 251_ DFGTH 256_ ISGRI 261_ IDCAF 266_ TVTFN 271_ PKYDT 276_ LLKAV 281_ KDATN 286_ TGIKC 291_ AGIDV 296_ RLCDV 301_ GEAIQ 306_ EVMES 311_ YEVEI 316_ DGKTY 321_ QVKPI 326_ RNLNG 331_ HSIGQ 336_ YRIHA 341_ GKTVP 346_ IVKGG 351_ EATRM 356_ EEGEV 361_ YAIET 366_ FGSTG 371_ KGVVH 376_ DDMEC 381_ SHYMK 386_ NFDVG 391_ HVPIR 396_ LPRTK 401_ HLLNV 406_ INENF 411_ GTLAF 416_ CRRWL 421_ DRLGE 426_ SKYLM 431_ ALKNL 436_ CDLGI 441_ VDPYP 446_ PLCDI 451_ KGSYT 456_ AQFEH 461_ TILLR 466_ PTCKE 471_VVSRG
1: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo
2: Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis