Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253)
1_MAMME 6_ VQGGP 11_ SLGQT 16_ CVLIV 21_ IFTVL 26_ LQSLC 31_ VAVTY 36_ VYFTN 41_ ELKQM 46_ QDKYS 51_ KSGIA 56_ CFLKE 61_ DDSYW 66_ DPNDE 71_ ESMNS 76_ PCWQV 81_ KWQLR 86_ QLVRK 91_ MILRT 96_ SEETI 101_ STVQE 106_ KQQNI 111_ SPLVR 116_ ERGPQ 121_ RVAAH 126_ ITGTR 131_ GRSNT 136_ LSSPN 141_ SKNEK 146_ ALGRK 151_ INSWE 156_ SSRSG 161_ HSFLS 166_ NLHLR 171_ NGELV 176_ IHEKG 181_ FYYIY 186_ SQTYF 191_ RFQEE 196_ IKENT 201_ KNDKQ 206_ MVQYI 211_ YKYTS 216_ YPDPI 221_ LLMKS 226_ ARNSC 231_ WSKDA 236_ EYGLY 241_ SIYQG 246_ GIFEL 251_ KENDR 256_ IFVSV 261_ TNEHL 266_ IDMDH 271_ EASFF 276_GAFLV
1: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis