E3 ubiquitin-protein ligase RNF144A (EC 2.3.2.31) (RING finger protein 144A) (UbcM4-interacting protein 4) (Ubiquitin-conjugating enzyme 7-interacting protein 4)
1_MTTTR 6_ YRPTW 11_ DLALD 16_ PLVSC 21_ KLCLG 26_ EYPVE 31_ QMTTI 36_ AQCQC 41_ IFCTL 46_ CLKQY 51_ VELLI 56_ KEGLE 61_ TAISC 66_ PDAAC 71_ PKQGH 76_ LQENE 81_ IECMV 86_ AAEIM 91_ QRYKK 96_ LQFER 101_ EVLFD 106_ PCRTW 111_ CPAST 116_ CQAVC 121_ QLQDV 126_ GLQTP 131_ QPVQC 136_ KACRM 141_ EFCST 146_ CKASW 151_ HPGQG 156_ CPETM 161_ PITFL 166_ PGETS 171_ AAFKM 176_ EEDDA 181_ PIKRC 186_ PKCKV 191_ YIERD 196_ EGCAQ 201_ MMCKN 206_ CKHAF 211_ CWYCL 216_ ESLDD 221_ DFLLI 226_ HYDKG 231_ PCRNK 236_ LGHSR 241_ ASVIW 246_ HRTQV 251_ VGIFA 256_ GFGLL 261_ LLVAS 266_ PFLLL 271_ ATPFV 276_ LCCKC 281_ KCSKG 286_DDDPL
1: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:26216882). Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage (PubMed:24979766). Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways (PubMed:37955227). Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination (PubMed:30171075). Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol (PubMed:33067254)